Hi all! I am a bit confused about this illness! Is it autoimmune or immune deficient? Some people have low NK cells and infections but the rituximab trial seems to suggest autoimmune. Can it be both or are there different subgroups who have a different illness? I have always been prone to allergies and I had a dermatologist tell me I had a twitchy immune system because of skin allergies I had and that was years before the ME and my mum died aged 24 of asthma, also rheumatoid arthritis runs in my family as well. On the other hand I seem to catch infections easily and I can't seem to keep them under control when I get them. The last bad relapse I had of the ME I broke out in eczema all over my arms and legs, which suggests something going on in the immune system.