Hi Rosebud, I don't think that would do the trick. If it did, then the doses I take on wakeup and other times duing the day would maintain my folate effectiveness. It helps but not without the doses taken with food or a minute before eating that is mixed with and has combined absorbtion. If the foilic acid and/or folinic are not blocked from being absorbed they end up blocking the Metafolin once they get in the blood. I can take the Metafolin all day without food and still have deficiency if I don't also take it with the food. I already tried that.