I have seen a number of people confiming in themselves various forms of folate deficiencies by elliminating folic acid, folinic acid, NAC, glutathione, whey and maybe some other things and trying Metafolin. I am right now working on a questiionaire for detecting these deficiencies. I would like anybody willing to post the specific symptoms that the see changing with the Metafolin. For me that ranges from the very fast changing ones; IBS, angular cheilitis (sores ar corner of mouth), nausea, malaise, increase allergy, asthma, inflammation, depression, irritability, cold feet, edema, lower potassium when folate deficiency corrected, to lower MCV, lower MCH, increased platelet count over a longer period. The more exact and specific you can be, the more hlepful this will be. Also please mention which items you found to be a problem for you. Thankyou.