bjl218
Senior Member
- Messages
- 145
- Location
- Chelmsford, Massachusetts
I've read a lot on this site, but I'm still confused about the effect of COMT SNPs. I believe it's Yasko's theory that COMT +/+ SNPs make one sensitive to methyl donors. Is this considered gospel or controversial? I have 2 homozygous COMT SNPS (see my sig). My recent NutrEval showed that I was very low in folate and other B vitamins. So how do I get methylation going unless I can take methyl-folate? I tried methyl-B12 and methyl-folate a few years ago and didn't seem to have any problems with them. Fast forward a few years and I ran into some serious anxiety problems when I tried to take various methylated supplements. My B2 was also very low and I've read that that can be a contributor as well. So I'm working on bringing up my B2 right now. But the whole COMT issue still concerns me.
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