Hey everyone. Going through heartfixer and have the following issues: COMT V158M rs4680 AG +/-COMT H62H rs4633 CT +/-COMT P199P rs769224 GG -/-VDR Bsm rs1544410 CT +/-VDR Taq rs731236 AG +/- As you can see, I'm +/- for both COMT and VDR. From my research, COMT +/+ means I degrade dopamine slowly, so I have more methyl groups floating around. But the VDR issue with +/+ means I need more methyl donoars to function properly. So since I'm +/-, I'm assuming I'm somewhere in the middle, but does this just cancel each other out? So the COMT has more methyl donors floating around, but then the VDR takes those methyl donors up? Here's the rest of my chart if it makes any difference: VDR Fok-I not found n/a n/aMAO A R297R rs6323 T +ACAT1-02 rs3741049 GG -/-MTHFR C677T rs1801133 GG -/-MTHFR 03 P39P rs2066470 GG -/-MTHFR A1298C rs1801131 GT +/-MTR A2756G rs1805087 AG +/-MTRR A66G rs1801394 AG +/-MTRR H595Y rs10380 CC -/-MTRR K350A rs162036 AG +/-MTRR R415T rs2287780 CC -/-MTRR S257T not found n/a n/aMTRR A664A rs1802059 AG +/-BHMT-01 not found n/a n/aBHMT-02 rs567754 CT +/-BHMT-04 rs617219 AC +/-BHMT-08 rs651852 CT +/-AHCY-01 rs819147 TT -/-AHCY-02 rs819134 AA -/-AHCY-19 rs819171 TT -/-CBS C699T rs234706 GG -/-CBS A360A rs1801181 AA +/+CBS N212N rs2298758 GG -/-SUOX S370S not found n/a n/aNOS3 D298E not found n/a n/aSHMT1 C1420T rs1979277 AG +/- thanks for any insights into this. heartfixer said regarding this combo: Multiple (+/-) combinations of COMT and VDR Taq are possible. We will address these “intermediate” genotypes with intermediate levels of methyl group supplementation. I will be more specific on your individual report.