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COMT/VDR Both Heterozygous

Discussion in 'General Treatment' started by rocky, Jun 13, 2013.

  1. rocky

    rocky

    Messages:
    19
    Likes:
    1
    Hey everyone.

    Going through heartfixer and have the following issues:

    COMT V158M​
    rs4680​
    AG​
    +/-​
    COMT H62H​
    rs4633​
    CT​
    +/-​
    COMT P199P​
    rs769224​
    GG​
    -/-​
    VDR Bsm​
    rs1544410​
    CT​
    +/-​
    VDR Taq​
    rs731236​
    AG​
    +/-​


    As you can see, I'm +/- for both COMT and VDR.

    From my research, COMT +/+ means I degrade dopamine slowly, so I have more methyl groups floating around. But the VDR issue with +/+ means I need more methyl donoars to function properly.

    So since I'm +/-, I'm assuming I'm somewhere in the middle, but does this just cancel each other out? So the COMT has more methyl donors floating around, but then the VDR takes those methyl donors up?

    Here's the rest of my chart if it makes any difference:
    VDR Fok-I​
    not found​
    n/a​
    n/a​
    MAO A R297R​
    rs6323​
    T​
    +​
    ACAT1-02​
    rs3741049​
    GG​
    -/-​
    MTHFR C677T​
    rs1801133​
    GG​
    -/-​
    MTHFR 03 P39P​
    rs2066470​
    GG​
    -/-​
    MTHFR A1298C​
    rs1801131​
    GT​
    +/-​
    MTR A2756G​
    rs1805087​
    AG​
    +/-​
    MTRR A66G​
    rs1801394​
    AG​
    +/-​
    MTRR H595Y​
    rs10380​
    CC​
    -/-​
    MTRR K350A​
    rs162036​
    AG​
    +/-​
    MTRR R415T​
    rs2287780​
    CC​
    -/-​
    MTRR S257T​
    not found​
    n/a​
    n/a​
    MTRR A664A​
    rs1802059​
    AG​
    +/-​
    BHMT-01​
    not found​
    n/a​
    n/a​
    BHMT-02​
    rs567754​
    CT​
    +/-​
    BHMT-04​
    rs617219​
    AC​
    +/-​
    BHMT-08​
    rs651852​
    CT​
    +/-​
    AHCY-01​
    rs819147​
    TT​
    -/-​
    AHCY-02​
    rs819134​
    AA​
    -/-​
    AHCY-19​
    rs819171​
    TT​
    -/-​
    CBS C699T​
    rs234706​
    GG​
    -/-​
    CBS A360A​
    rs1801181​
    AA​
    +/+​
    CBS N212N​
    rs2298758​
    GG​
    -/-​
    SUOX S370S​
    not found​
    n/a​
    n/a​
    NOS3 D298E​
    not found​
    n/a​
    n/a​
    SHMT1 C1420T​
    rs1979277​
    AG​
    +/-​



    thanks for any insights into this. heartfixer said regarding this combo: Multiple (+/-) combinations of COMT and VDR Taq are possible. We will address these “intermediate” genotypes with intermediate levels of methyl group supplementation. I will be more specific on your individual report.
     
  2. caledonia

    caledonia

    Messages:
    3,247
    Likes:
    1,991
    Cincinnati, OH, USA
    Yasko has a very nice chart regarding this on her new Simplifed Roadmap. See the link in my signature. For your situation, she suggests Hydroxy B12 and Adenosyl B12.
     
    frenchmoxie and rocky like this.
  3. rocky

    rocky

    Messages:
    19
    Likes:
    1
    awesome, thank you for the post. now i know what i need! :)
     

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