I have double COMT +/+ mutations and I am trying to figure out ways to break down dopamine/norep/epinephrine quicker. I've been taking hydroxyb12 and adb12, but once I started the methylfolate a couple weeks later I either overmethylated/ or methyltrapped BAD. I got some terrible mood swings, insomnia, anger, depression, extra fatigue,etc. I figure that the Hydroxyb12 is not quite doing it for me so I want to start methylb12. I'm just afraid that once I get things moving a bit I won't be able to break down dopamine and its byproducts quickly enough. The problem is made worse by the fact that I have MTHFR C677T+/+ BHMT+/+ MTRR +/+ and MTR +/- Mutation So I'm gonna need extra B12 also and be bad at recycling b12. Here is the Genetic Genie, although BHMT is -/- there and +/+ from sterlings app. http://postimg.org/image/em0mtlnz5 Any ideas? Thanks!