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COMT mutation and intolerance to methyl groups

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by soundasacrystal, Jul 27, 2017.

  1. soundasacrystal

    soundasacrystal

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    Can anyone help me understand this better?

    I suspect but do not know that I have the COMT gene mutation because of the way I react to methylated forms of folate and B12. In the past I have had severe panic attacks, insomnia, and even seizures after taking these things. But I suspect that they are an important part of the healing puzzle, so I would like to understand this better.

    Any insights on what this is and what can be done about it?
     
  2. alicec

    alicec Senior Member

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    There's no evidence that COMT SNPs affect tolerance of methyl groups.

    This was a theory of Yasko's that became self-fulfilling. Because such people MIGHT be sensitive to methyl groups they weren't given them. At some point this was claimed as a known fact - ie that such people WERE sensitive to methyl groups and SHOULDN'T be given them.

    There are no studies to support the claim and plenty of people who are COMT +/+, including myself, have put the theory to the test and found it wanting. I am not sensitive to methyl groups nor are many other people of PR.

    Conversely, some people who are COMT -/- report sensitivity to methyl groups.

    As for the basis of the sensitivity, there could be many reasons for it and it's probably a very individual thing.
     
  3. sb4

    sb4 Senior Member

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    What @alicec said is probably right.

    I have comt mutations and seem to really struggle with anything that increases catecholamines. This includes methylfolate. So that could be random or it could back up that theory.
     
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  4. caledonia

    caledonia

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    Cincinnati, OH, USA
    You can use some niacin to cushion things.

    See my document "Roadblocks to Successful Methylation Treatment" in my signature link.
     
    soundasacrystal likes this.

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