Can anyone help me understand this better? I suspect but do not know that I have the COMT gene mutation because of the way I react to methylated forms of folate and B12. In the past I have had severe panic attacks, insomnia, and even seizures after taking these things. But I suspect that they are an important part of the healing puzzle, so I would like to understand this better. Any insights on what this is and what can be done about it?