it seems that COMT mutations are critical to neurological health, to adrenal health and in many cases they can define in a percentage the personality of a person. There are people that have COMT status especially when they are homozygous in both COMT mutations that trigger a severe reaction when they are supplementing with methyl donors and/or other b vitamins as b6. The picture gets more complicated if you add MAOA in to the mix, as having COMT status means higher concentration of dopamine in the brain and MAOA means higher reuptake of serotonin in the brain by the receptors resulting in even larger amounts of dopamine and low serotonin resulting in high anxiety and adrenal exhaustion. Also we often meet this pattern status of mutations to people that are trying to supplement with methylfolate and they do get severe side effects from it. And then there is also the Gaba/glutamine balance to consider. When glutamine is much higher in concentration than gaba it is causing excitotoxicity in the brain that damages the nerves and maybe this is a reason that supplementation could get you worse if you try it. Various "Expert" doctors say that in these cases where supplementation gets you worse even though you are giving to your body what it is actually inadequate and especially when this has to do with b vitamins you have to consider dealing with underlying problems first that has to do with nerves before starting supplementation. I am looking for opinions about my views, also I am looking with people that have this pattern of snps (both COMT homozygous also MAOA homozygous and possibly the MTHFR C667) and they are doing good with the treatment they receive.