The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Complex diseases may have a simple trigger--brain infecting microbes

Discussion in 'Other Health News and Research' started by Snowdrop, Mar 22, 2016.

  1. Snowdrop

    Snowdrop Rebel without a biscuit

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    Antares in NYC, merylg and duncan like this.
  2. Dufresne

    Dufresne almost there...

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    Montreal
    I've heard of them finding evidence of spirochetes in the brains of Alzheimer's patients and I wonder why this hasn't been replicated. Has anybody tried? If they can find Bb in Otzi's knee, why wouldn't they be able to find it in the tissues of people who recently died?

    Can NGS be used on tissues at this point?
     
  3. Snowdrop

    Snowdrop Rebel without a biscuit

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    Let's hope that they do replication studies if not done already. I'm not science literate so can't answer any science questions but I do think that we may benefit tangentially from this kind of research.
     
  4. anciendaze

    anciendaze Senior Member

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    Because of the variety of pathogens seen in several postmortem studies of brains of Alzheimer's patients, I'm leaning toward damage to immune systems as a cause rather than any single pathogen. We may be dealing with a total pathogen load rather than the classic kind of infectious disease. The problem this raises is that we don't have good ways to measure effectiveness of immune response or general pathogen load prior to some kind of explicit failure.
     
  5. Hip

    Hip Senior Member

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  6. Snowdrop

    Snowdrop Rebel without a biscuit

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    Ah yes, and I even read it recently too--and didn't connect (obviously) to reading the article.
    There is a longer discussion on the thread Hip posted a link to.
     

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