Hi heaps, took me a while to see this. Tianeptine is definitely calming for me, but not sedating at all. ' Tianeptine is a selective serotonin reuptake enhancer (SSRE), opposite to the action of SSRIs. Tianeptine enhances the extracellular concentration of dopamine in the nucleus accumbens and modulates the D2 and D3 dopamine receptors, but this effect is modest and almost certainly indirect. There is also action on the NMDA and AMPA receptors. Recent reviews point to this pathway as a hypothesized mechanism of action, based on tianeptine's effect of reversing impaired neuroplasticity associated with stress'. wiki It's done the job for me. Hasnt interfered with sleep or sexual function. It just leaves me clear. It would be nice if it had some motivating effect too, but it hasnt done that. I sort of like Hip's prescription though. I would like to try that. My long term aim is always to take the least amount of medication i can. Though this is sometimes not a reality. I've ordered some some NAG and bioavailable curcumin to go with the flax oil i already take. This is a great thread. I love all us supplement/medication voyagers.