That is a very plausible theory. Bravo! I also wanted to add, that free-form gltuamates are in abundance in almost all processed food. Russell Blaylock has a great presentation on it here: Again, I will ask, what is causing Mast Cell activation? I think I am inclined to agree with Hip, that the cause is most likely all manner of pathogens. I would also add that using the Yasko multi-factorial approach, there are numerous environmental toxins and genetic defects creating a pre-existing overburden on the immune system. Once those underlying fundamentals are effectively dealt with the body can take care of the pathogens. The pathogens merely being the straw that broke the camels back. That being said, what are some of the best ways to arm the body against pathogens? I picked myself up some NAG today, perhaps it will help buff my 1st line of defense against these insidious pathogens.