One of my ME symptoms is a practically complete loss of feelings. I don't feel full, hungry, happy, sad, touch, heat and more. So it goes beyond the just not feeling positive things, also the negative things aren't there. With practically not feeling, I mean that it's like there's a drop of water where there used to be a full bucket. If I try to get artificial stimuli (such as medications known to release dopamin, serotonin, endorphins), that does nothing as well. So, I have concluded that my problems are most likely on a receptor level, instead of a lack of neurotransmitters. Do you have this as well? Or something similar to this? Of the hundreds of patients I've been in touch with, I know of only two other whom have it.