Any thoughts, experiences on both these protocols? I am interested in the types of FA and B12 and the dosing, the active b12 protocol being very high dose and the simplified low dose.. I am also interested in how "yasko" snps could play into th active b12 protocol (do I have the name correct?)... Example: I am COMT++,++ and I do think that I cannot tolerate too many methyl groups. I can feel the adrenaline surgeing and staying.. I seemed to be able to tolerate 5-10 mg of MB12 (which I am told in yasko terms is alot of MB12 for a COMT++,++) and 400 mcg of metafolin. I was also taking about 400mcg of folicin but took that out as per Freddd (active B12 protocol) and then uppedthe metafolin to 2400mcg a day.. adrenaline crash resulted from that. I am MTHFr +- for both snps and MTR++/MTRR+- for quite a few MTRR snps.. so this means I need the methyl form of FA for sure (MTHFr) and at least alot of hydroxo b12 and or methyl b12... (I think yasko recommends as much as you can get for MTR,MTRR folks but could have that wrong) and for COMT++ folks, only HB12 becasue too many methyl groups can result in hyper adrenaline states. I am wondering as per Freddd as I understand the protocol about yasko's dosing for metafolin.. he says half life of 3 hours and doses throughout the day.. I think up to 4 times a day because of that.. and way past yasko doses... into the 1000s of mcgs.. deplin like doses. while yasko is at 300 mcg and seems once a day is fine.. How does methylation work here.. where is yasko (thus rich) justified and freddd justified in that cycle??? I have questions regarding both.. why so low dose and only once a day with yasko on the metafolin? Why so much b12 and so little metafolin with yasko? IS the halflife info correct with the metafolin? and is so much needed as per freddd? Do we become methylfolate deficient? or do we use it up so fast and or inefficiently even if in the most active form? Same for Mb12... and what is the difference between a defiency that cannot be eventually "filled" and a dependency due to genetic flaws? How would folinic create a methyl trap? What are the benefits of folinic and issues that could come up if one does not supplement for it? What does tetrahydrofolate do in the body that the methyl form can't? Can freddd's protocl over drive merthylation and how would you know? Do active b12 and FA need to be in body at same time to make methylation work or do we dump them out rather quickly...? I was recenlty on 800 mcg metafolin, 400mcg per dosing.. 10 mg MB12.. 5mcg per dose.. still too much adrenaline. I was fine on 5-10 Mb12 and 400 mcg metafolin and 400mcg folinic for a long while.. no lingering adrenaline surges.. I am now experimenting with 800mcg metafolin and Hb12.. yesterday.. no adrenaline surges.. today 400mcg metafolin and 5mg MB12.. adrenaline.. Thank you!!!!!