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Knitting Equals Pleasure, Despite ME/CFS
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Combo rituximab and thalidomide analogues stimulate nk function

Discussion in 'Rituximab: News and Research' started by heapsreal, Dec 6, 2011.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Summary
    The immunomodulatory drugs (IMiDs) lenalidomide and actimid (also
    known as CC-4047) are thalidomide analogues which are more potent than
    their parental compound. In combination with rituximab, we have previously
    demonstrated that IMiDs have synergistic in vivo anti-tumour activity in
    preclinical studies in a human lymphoma severe combined
    immunodeficiency mouse model. This report further explored the
    mechanisms by which IMiDs exert their anti-lymphoma effects. Following
    exposure of subcutaneous lymphoma tumours in murine models to IMiDs,
    there was a significant increase in the recruitment of natural killer (NK) cells
    to tumour sites. This increase in NK cells was mediated via stimulation of
    dendritic cells and modification of the cytokine microenvironment associated
    with an increase in monocyte chemotactic protein-1, tumour necrosis factora
    and interferon-c and probably augmented rituximab-associated antibodydependent
    cellular cytotoxicity. IMiDs also had significant anti-angiogenic
    effects in our B-cell lymphoma models. Thus, by modulation of the immune
    system mediated via dendritic cells and NK cells, changing the cytokine
    milieu, as well as by their anti-angiogenic effects, IMiDs in combination with
    rituximab resulted in augmented in vivo anti-tumour effects against B-cell
    lymphoma. Our positive preclinical data adds additional support for the
    evaluation of IMiDs plus rituximab in patients with relapsed/refractory B-cell
    lymphoma.


    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06841.x/pdf

    If auto-immune or not, increasing nk function is going to help cfs/me if chronic infections are the cause. Interesting finding research showing correlations with nk function and ritux. Im thinking there is a very strong overlap of viral infections and auto-immune diseases, i just wonder if/when cfs/me mystery is solved if it will also solve other conditions and auto-immune illnesses??

    cheers!!
  2. niall

    niall

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    I read with interest your information on Thalidomide analogues. When I saw Dr. Klimas in 2006, Thalidomide was one of the drugs mentioned in her assessment of how to treat my illness. She never discussed putting me on it though, but prescribed Imunovir as the least toxic approach.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Interesting niall, i have also read about thalidomide in the book, 'reviving the broken marrionette' which was pre the recent rituximab study. I think alot of these things have already been researched but need to be done several times(or hundreds) before its taken as gosspel.

    How did imunovir effect you??

    cheers!!!
  4. niall

    niall

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    The first time I took it for the six months, I got most of my energy back and significant reduction in muscle pain but continued to have the reddened irritated throat. That lasted about seven months then a sudden return to my original symptoms. The last time I took it (I finished in August) I only got a modest increase in energy while continuing to have head aches, pulsating in head, sore throat and myalgia.
  5. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    did your nk function and or numbers increase??
  6. niall

    niall

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    I did not have an NK blood test for at least three years before starting Ampligen in October 2011. Pre-Ampligen NK number was 9.99% and the activity was 31.44%, all normal. However, I felt terrible and my viral titers to EBV and HHV6 were quite high.
    redrachel76 and heapsreal like this.

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