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Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes in CFS

Discussion in 'Genetic Testing and SNPs' started by Beyond, Oct 18, 2013.

  1. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Murcia, Spain
    Thanks nandixon, upon reading these reports and others I realised some researchers are suggesting high serotonin in CFS. I don´t now if I personally I have high serotonin, but 5-HTP made me get bad depersonalization so I have the serotonin pathways messed up for sure.

    I am also homozigous AA for the other rs of TPH2 that you provided. And homozigous AA for all the TAAGA rs´s. How is your HTR2A rs6311? That one is an upregulation.

    Moreover, I have some clear degree of OCD and it has been long suspected that is related with abnormal serotonin metabolism. Actually all the meds that help OCD raise serotonin levels and mine was lowish last time tested. 141 ng/ml, range being 100 -283.

    It seems that 5-HT genes and pathways influence HPA axis a lot. Not to mention the HPA genes themselves. Genetic research is very exciting!

    http://onlinelibrary.wiley.com/doi/10.1111/j.1601-183X.2010.00564.x/full http://www.nature.com/mp/journal/v11/n10/full/4001870a.html
    http://www.sciencedirect.com/science/article/pii/S0306453097000024
    http://www.sciencedirect.com/science/article/pii/S0165032797001018

    Furthermore, my multiple GAD1 mutations are consistent with the EXTREMELY low GABA result of these 2011 urine tests.
  2. nandixon

    nandixon Senior Member

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    I'm CC for rs6311, so homozygous for the most common allele.
  3. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Adding more evidence about the genes in the spotlight for CFS:

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765429/

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