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Cold sores may be tied to memory loss, study suggests
By Steve James, NBC News contributor
Researchers have found that the virus that causes cold sores, along with other viral or bacterial infections, might be associated with memory loss, and if further studies establish such a link, it could eventually prove helpful in preventing strokes or Alzheimer’s disease.
A long-term study of a group of people in one neighborhood of New York City found that those with higher levels of infection in their blood -- meaning they had been exposed to various pathogens such as the herpes simplex type 1 virus that causes cold sores -- were more likely to have cognitive problems than people with lower levels of infection in the blood. The results, released Monday, are published in the March 26 issue of Neurology, the medical journal of the American Academy of Neurology....
The study, performed in collaboration with the Miller School of Medicine at the University of Miami, tested thinking and memory in 1,625 people from northern Manhattan who had an average age of 69. Participants gave blood samples that were tested for five common low grade infections: three viruses (herpes simplex type 1, which is oral; herpes simplex type 2, which is genital; and cytomegalovirus), chlamydia pneumoniae (a common respiratory infection) and Helicobacter pylori (a bacteria found in the stomach).
This is the study:
Infectious burden and cognitive function
The Northern Manhattan Study
Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time.
Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was −0.77, p < 0.0001, and for first measurements of TICS-m was −1.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = −0.17, p = 0.06, for TICS-m adjusted change per SD IB = −0.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06–1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only.
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Note: An earlier viral study with results on other health issues as most ME/CFS patients have high titers of EBV, HHV6, CMV, Parvovirus B19, etc.
Eco
By Steve James, NBC News contributor
Researchers have found that the virus that causes cold sores, along with other viral or bacterial infections, might be associated with memory loss, and if further studies establish such a link, it could eventually prove helpful in preventing strokes or Alzheimer’s disease.
A long-term study of a group of people in one neighborhood of New York City found that those with higher levels of infection in their blood -- meaning they had been exposed to various pathogens such as the herpes simplex type 1 virus that causes cold sores -- were more likely to have cognitive problems than people with lower levels of infection in the blood. The results, released Monday, are published in the March 26 issue of Neurology, the medical journal of the American Academy of Neurology....
The study, performed in collaboration with the Miller School of Medicine at the University of Miami, tested thinking and memory in 1,625 people from northern Manhattan who had an average age of 69. Participants gave blood samples that were tested for five common low grade infections: three viruses (herpes simplex type 1, which is oral; herpes simplex type 2, which is genital; and cytomegalovirus), chlamydia pneumoniae (a common respiratory infection) and Helicobacter pylori (a bacteria found in the stomach).
This is the study:
Infectious burden and cognitive function
The Northern Manhattan Study
- Mira Katan, MD,
- Yeseon Park Moon, MS,
- Myunghee Cho Paik, PhD,
- Ralph L. Sacco, MD, MS,
- Clinton B. Wright, MD and
- Mitchell S.V. Elkind, MD, MS
- Correspondence to Dr. Katan: mk3270@columbia.edu
- doi: 10.1212/WNL.0b013e3182896e79 Neurology March 26, 2013 vol. 80 no. 13 1209-1215
Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time.
Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was −0.77, p < 0.0001, and for first measurements of TICS-m was −1.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = −0.17, p = 0.06, for TICS-m adjusted change per SD IB = −0.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06–1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only.
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Note: An earlier viral study with results on other health issues as most ME/CFS patients have high titers of EBV, HHV6, CMV, Parvovirus B19, etc.
Eco