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Coenzyme Q10 and Ubiquinol

Discussion in 'General Treatment' started by Lotus97, Mar 19, 2013.

  1. Lotus97

    Lotus97 Senior Member

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    The topic of this thread is anything related to coenzyme Q10 and ubiquinol, but I'll start off with some questions.
    1. When CoQ10 is measured in the body, are they measuring ubiquinone or ubiquinol? My understanding is that ubiquinone (which most coenzyme q10 supplements are unless labeled ubiquinol) needs to be converted to ubiquinol to be used. That leads me to my second question
    2. What factors affect how well a person converts ubiquinone to ubiquinol? I read something about people over 40 recommended to take ubiquinol instead of ubiquinone.
    3. When someone naturally produces coenzyme q10 do they produce ubiquinone and then need to convert it to ubiquinol?
     
  2. Plum

    Plum Senior Member

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    I took ubiquinol for a while. Was told it is in the form your body uses and doesn't need converting. Apparently you can take a much smaller amount of ubiquinol than coenzyme q10. It made me very wired and I didn't like it at all.
     
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  3. lnester7

    lnester7 Seven

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    I tried both, I do better on COQ10.
     
  4. Mij

    Mij Senior Member

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    Lotus,

    I'm looking at my CoQ10 results and the report reads as though they measured ubiquinone.

    I take Ubiquinol, 100mg.
     
  5. Lotus97

    Lotus97 Senior Member

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    Ubiquinol is more potent, but it's also 4 times as expensive as coenzyme Q10 so I don't know if it's a better value. Right now I'm taking 100 mg CoQ10 3 times a day. I like splitting up my doses throughout the day (with a lot of my supplements, not just coq10). Vitacost is having a buy one get one half off sale on ubiquinol so I might get some.

    I'd still like to know what they mean when they test a person's coenzyme q10 levels. Are they referring to ubiquinone or ubiquinol or does it depend on which test?

    triffid113 was saying that a person's methylation status and thyroid condition play a part in converting ubiquinol (coenzyme q10) into ubiquinol which is part part of the reason why I'm considering switching to ubiquinol until I get methylation working properly.
     
  6. CatherineF

    CatherineF

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    I am taking 100mg of ubiquinol x 2 and see no effects unfortunately.
     
  7. sianrecovery

    sianrecovery Senior Member

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    I've taken it in both forms. Never saw dramatic results. Will try and find my myhill tests and see which form she tested it in.
     
  8. Lotus97

    Lotus97 Senior Member

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    One thing I should mention is that it's recommended coenzyme Q10/ubiquinone and ubiquinol with a fat containing meal to absorb them since they are fat-soluble.

    I have read several customer reviews claiming ubiquinol worked better than coenzyme Q10. However, I came across an article that talks about the differences between ubiquinol and ubiquinone. I don't know enough to know whether all the information is correct, but the author seems to suggest that ubiquinol isn't much better than ubiquinone.
    http://ubiquinolubiquinonedebate.blogspot.com/
    I hope someone can go through the entire article and share whether everything is correct, but I'll post some of what the person says. The do it in a true/false format to refute certain claims. I'll just post what the person says is true, but if someone reads the article it can be sort of confusing since the person states claims that are both fact and fabrication.
    • The oxidized Ubiquinone form of CoQ10 is synthesized in the body's cells.
    • Reduced CoQ10 is highly unstable in the contents of the stomach and is converted to oxidized CoQ10 before absorption.
    • CQ10 can be converted from the reduced to oxidized form and vise versa in the body as needed.
    • Ubiquinone and Ubiquinol, being redox pairs, are easily converted from one form to the other in the body. For example, when exogenous Ubiquinone is absorbed in the intestines it is converted to Ubiquinol in the absorption cells, the lymph, or the blood. Since CoQ10 is not used to produce energy in the lymph system or blood, it is understandable why this conversion takes place to fulfill the need for antioxidant protection in the circulation. On the other hand, in the inner membrane of the mitochondria where energy is made, the oxidized form of CoQ10 (Ubiquinone) is in great demand. Here the reduced Ubiquinol form is rapidly converted to the oxidized Ubiquinone form.
    • The two hydroxyl groups on the Ubiquinol compound results in its stronger bonding with water and helps explain why it is so much more bioavailable than Ubiquinone. This bonding does make Ubiquinol slightly more water soluble than Ubiquinone. However, the molecule is still lipophilic and is absorbed as a lipid.
    • The data on ubiquinol state that its bioavailability is 300 percent more than that of the oxidized dry powder products. Most dissolved, liposome, micelle and nanoparticle CoQ10 products claim to have a 260 to 350 percent greater bioavailability than oxidized dry powder CoQ10.
    • Ubiquinone is a cofactor in the inner membrane of the mitochondria for the synthesis of energy (ATP). Since the body does not store energy (ATP), it must be rapidly produced through an oxidative phosphorlation process. CoQ10 is positioned between NADH and Cyto-Chrome C in the inner membrane and acts as cofactor stimulation to all three mediators to give up electrons to run the electron transport through complexes I-IV in this system. This function is specific to Ubiquinone in that no other molecule can replace Ubiquinone in this process. However, Ubiquinone and Ubiquinol as a redox pair form the Q Cycle in which they act to conserve each other in this process.
    • Ubiquinol is an antioxidant throughout the body. This is especially true in the cell membranes and those of the cell organelles. In these membranes CoQ10 may well be the primary lipophilic molecule essential for the prevention of lipid peroxidation resulting in cell damage and eventually cell death. Outside the cell and organelle membrane and in the presence of other lipophilic and hydrophilic antioxidants, Ubiquinol may recycle other antioxidants such as vitamin E and C.
    • Ubiquinol protects the body against toxic oxidative reactions. It also recycles Ubiquinone in the synthesis of energy.
    • Ubiquinol functions in the body as an antioxidant and in the recycling of Ubiquinone, Vitamin E and Vitamin C. Ubiquinone, through its synthesis of energy, is involved in all body processes requiring energy: energy synthesis, active transport, membrane and nucleotide stability, synthesis of enzymes, coenzymes, hormones, neuro-transmitter synthesis and reuptake, cillary activity in the upper respiratory systems, all muscle contractile functions, sperm production and motility, deactivation of muscle contraction, pumping action of sweat and other cutaneous glands, etc. In fact, Ubiquinone is possibly the hub around which life processes revolve in the human body.
    One thing to mention is that the article was written in 2007 and the person said there were no studies published in peer-reviewed scientific literature. There were some studies mentioned in wikipedia, but I don't know if they were published in peer-reviewed scientific literature. Nor do I understand the signficance of being published in peer-reviewed literature.

    From wikipedia
    http://en.wikipedia.org/wiki/Ubiquinol
     
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  9. L'engle

    L'engle moogle

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    I've tried both kinds. Ordinary CoQ10 made me wired and have trouble sleeping. Ubiquinol made me feel so weird (weird as opposed to wired) I never wanted to try it again. I have to stay away from anything that causes wiredness as it just makes me more run-down.
     
  10. Lotus97

    Lotus97 Senior Member

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    I've heard coenzyme q10 mentioned as a methyl donor. Would it be enough to contribute to overmethylation for sensitive individuals?
     
  11. perchance dreamer

    perchance dreamer Senior Member

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    I used 100 MG of ubiquinol for a long time. I could never tell any effect one way or another.

    I switched to a crystal-free COQ10 instead. It's supposed to be highly absorbable. Interestingly, I can only do 50 MG of it, or it affects my sleep.

    I still can't tell any effect with it, but I take it hoping there's some benefit anyway. When I tried 100 MG, I did have more energy.
     
  12. adreno

    adreno PR activist

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    http://www.sciencedirect.com/science/article/pii/S175646460800011X
     
  13. jimells

    jimells Senior Member

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    I started taking Co Q10 (the regular over-the-counter kind) last summer after I found a review of migraine preventatives (sorry, I can't find it again). The review reported pretty good results with Co Q10. After two or three months I noticed a decrease in severity and frequency of migraine attacks. The migraines continue to improve, especially when I manage to avoid PEM.

    A big part of the improvement seems to include a reduction in light and sound sensitivity - I think of it as turning down the ''sensitivity control knob' in my brain. I used to wake up and put in earplugs (the kind used by musicians - they let low volume sounds through) until my cockatiels finished giving me their morning greetings. I did this every day, even on days when I didn't have a migraine attack. It's now been quite a few months since I've last used the earplugs.

    I am very disturbed that no doctor in ten years of being sick has ever suggested Co Q10. They are, of course, anxious to get me hooked on some horrible antiseizure medication. Thanks, but no thanks.
     
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  14. adreno

    adreno PR activist

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    It's settled; ubiquinol is superior to ubiquinone:

    http://onlinelibrary.wiley.com/doi/10.1002/cpdd.73/full
     
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  15. TheWig

    TheWig

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    Ubiquinol is the form you want to supplement. It's more expensive, but its the form that the body can absorb and utilize far more readily.
     

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