Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

cobalt can cause goiter (as in cobalt from B12)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by triffid113, Apr 19, 2013.

  1. triffid113

    triffid113 Day of the Square Peg

    Messages:
    702
    Likes:
    258
    Michigan
    I just want to share this info from www.thyroidmanager.org:

    Cobalt. Cobalt inhibits iodide binding by the thyroid.105 The mechanism is unknown. Cobalt deficiency is associated with a reduction in type I monodeiodinase activity and a fall in T3105a while cobalt excess may produce goiter and decreased thyroid hormone production. 105b It is sufficiently active to have been used in the treatment of thyrotoxicosis.106

    Also I want to mention that my hair analysis at age 45 showed no elevated cobalt, but at age 51, yes HIGH cobalt...my guess is from B12 supplements. It did not affect me that much...my TSH when not during allergy season is 2.3 (should be below 2.0) but TSH >=2.0 raises cholesterol (which raises blood pressure) so it is something to avoid if at all possible. To be fair I also take a cruciferous vegetable extract and broccoli is supposedly a goiterogen. Life Extension brand and they told me it would not cause problem (but never gave me a reason why). I take the broccoli because it makes my hormones come out right...so to avoid breast cancer. [Hey! I don't know everything! But I don't like that my cobalt came out HIGH on my tests].
     
    golden likes this.
  2. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,020
    How much B12 are you taking?
     
  3. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

    Messages:
    4,665
    Likes:
    5,480
    My cobalt is still barely detectable. What are the consequences of “a reduction in type I monodeiodinase activity and a fall in T3105”?
     
  4. triffid113

    triffid113 Day of the Square Peg

    Messages:
    702
    Likes:
    258
    Michigan
    Ugh. I typed a response and my cat rubbed her head on my pc and I lost it! Arghgh!

    I have found a few useful bits of info:
    cysteine protects against cobalt toxicity (http://www.ncbi.nlm.nih.gov/pubmed/3298579)
    melatonin protects brain cells from cobalt (http://onlinelibrary.wiley.com/doi/10.1034/j.1600079X.2001.310406.x/abstract)

    Also this study says zinc helps prevents testiculardamage from cobalt:
    http://www.sciencedirect.com/science/article/pii/089062389390009V

    I take a broccoli pill every day (which surely contains cysteine?)

    Triff
     
  5. triffid113

    triffid113 Day of the Square Peg

    Messages:
    702
    Likes:
    258
    Michigan
    I am taking 400-850 mcg mB12/day. Now. But in the past I took that Jarrow mB12 sublingual 1-2x/day to get 5000-10000 ADDITIONAL mcg of mB12/day. As I stepped up to the mB12 band wagon. I did that for at least a year before I tested my homocysteine w/o the sublingual and decided I did not need it. I need to get a new hair analysis. At age 45 I was taking 100mcg cyanoB12/day as part of my non-active B100.

    Excessive cobalt causes hypothyroid (goiter) and cardiomyopathy and Alzheimer's and it degrades the testicles. At least there is one thing on that list I don't have to worry about!

    Also one of the symptoms of too much cobalt is puking...and I puke if I take too many vitamins...I got to a max pill limit of 40 and when my doc prescribed more it became a puke problem and I started to try to prioritize and test to see if I really needed everything. The thing is I DO have the genetic defects that say I need active B12. I do not believe I have an intrinsic factor deficiency.
     
  6. adreno

    adreno PR activist

    Messages:
    4,843
    Likes:
    11,020
    Someone will have to chime in if this is uncorrect:

    http://wiki.answers.com/Q/How_much_cobalt_is_in_1000mcg_Vitamin_B-12

    It looks like this dose of cobalt is unlikely to cause problems:

    http://www.vkm.no/dav/ebc8d55983.pdf

    So even 10mg would provide not even a third of the guidance value. However, for those taking 30-40mg daily there could be a risk.
     
    Little Bluestem likes this.
  7. dbkita

    dbkita Senior Member

    Messages:
    655
    Likes:
    319
    I agree with Adreno. The amount of cobalt absorbed is miniscule relative to the LOAEL. If you are experiencing emesis taking too many pills I would suspect it has far more to do with how many and what type of pills and their effect on your stomach environment. I take 7500 mcg of mb12 and adb12 per day and my hair analysis results for cobalt show virtually none.
     

See more popular forum discussions.

Share This Page