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Cobalamin deficiency results in severe metabolic disorder of serine and threonine

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by SaraM, May 17, 2012.

  1. SaraM

    SaraM Senior Member

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    http://www.ncbi.nlm.nih.gov/pubmed/11750758

    I have threonine deficiency and a very low level of serine, and I have been taking a moderate daily dose of B12(1-5 g) for the last two years.



     
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  2. Lotus97

    Lotus97 Senior Member

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    I have a hard time understanding all the technical jargon in these articles. Are you saying that B12 caused the low levels of threonine and serine?
     
  3. AFCFS

    AFCFS Senior Member

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    Not sure if this helps to answer your question. There are many "caveats" to all this; basically just an interpretative overview, and needed to string together a few sources to show the B12 as a co-factor for the BCAAs that seem to be indicated if Low Threonine/Low Serine.
    (not all formatting is maintained)

    Interpretive Guide for Amino Acids
    BCAAs: BRANCHED-CHAIN AMINO ACIDS Overview Information
    What are the important co-factors in taking BCAAs as supplements?
     
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  4. dbkita

    dbkita Senior Member

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    Unless I am misinterpreting something, I think the abstract does not suggest a threonine / serine deficiency but a disorder in their metabolism and the reactions they are involved in, particularly the SDH conversion to pyruvate.

    Since the SDH reaction is downgraded, the body builds up serine and threonine in the plasma and excretes it at high levels.

    The people on here who have threonine or serine deficiency do not fit this pattern. They will have high serum / plasma and /or urine measurements. These animal tests suggest high measured levels of serine and threonine in serum and urine due to blocks in key reactions due to Cbl deficiency.

    Seem like an interesting article though. Will have to see if I can track the actual document down at work.
     
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  5. AFCFS

    AFCFS Senior Member

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    I think you are right. It is a bit interesting though that the B12 help adjust their metabolism (per the article), but may also be kind of an ancillary aid if they are low/deficient (per the other posting).
     
  6. CloudD790

    CloudD790

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    I have heard, I think on Heart-Fixer, that CBS+ mutations can cause a greater need for serine. Do you have a CBS mutation?
     
  7. Valentijn

    Valentijn Senior Member

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    The CBS variants listed by Yasko or Genetic Genie do not have a substantial impact. One has a tiny impact on gene function, and the other two do absolutely nothing.
     
  8. CloudD790

    CloudD790

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    I'm CBS C699T +/+ and A360A +/- and I'm not sure if its a blessing or a curse like almost everyone else who knows there's more to it than what Yasko let on in the Autism book.

    You seem to be saying they are meaningless, am I right?
    I the gene your refering to impacted by them MTHFR?

    I've only got MTHFR C677T +/- the other two on GeneticGenie are ok.. I just want to detox myself before I am likely to get CFS because my enzymes will all work better then post detox so I should avoid it. Although it'd be nice to know more about CBS so I have an idea as to whether I'm wasting money taking MeCbl ect. and having all my methyl inputs going down the "CBS drain".
     
  9. Valentijn

    Valentijn Senior Member

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    CBS A360A is completely meaningless. CBS C699T has an impact, but it's very mild and it's beneficial. Neither of them is capable of causing problems.

    No, the CBS SNPs can impact the CBS gene. But those specific SNPs don't really have any meaningful impact.

    There's no CBS drain. That concept can be traced back to Yasko's inexplicable misinterpretation of a CBS gene study which did not involve those specific SNPs.

    In that case, half of the entire gene was removed, which caused the enzyme activity to become up-regulated by a factor of 10 or more. But it is completely senseless to use that study to claim that CBS C699T somehow has the same effect, especially when actual research into C699T shows it is quite a mild variant.
     

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