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CNS inflammation, Autism and Clostridium - how to test

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by roller, Jan 21, 2016.

  1. roller

    roller wiggle jiggle

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    The links are many - Clostridium and CNS inflammation.
    https://en.wikipedia.org/wiki/Clostridium

    One reason, that the inflammation may be neglected is that they cant really test it.
    how annoying - once more.

    Perhaps anyone knows or has an idea, all appreciated:
    How to test for late stage tetanus?

    I understand they do (reasonably priced) IgE testings.
    but i suppose this is to verify the effectiveness of a tetanus vaccation.
    Or could this iGE-test reveal anything about a naturally contracted recurring/ongoing chronic tetanus inflammation as well?

    Is tetanus supposed to 'go away' or wear down after years?

    I cant find any sources about this.
    Seems to be considered peanuts by the medical experts..?
    Any help appreciated :)


    An FDA report from 2005 titled “Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Tripedia” outlines a number of adverse events reported during post-approval use of the Tripedia vaccine, and one of them is autism. - http://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm101580.pdf
    from http://www.sb277.org/vaccines-and-autism.html

    Autism and Clostridium tetani

    Bolte ER.
    Autism is a severe developmental disability believed to have multiple etiologies. (...)
    The vagus nerve is capable of transporting tetanus neurotoxin (TeNT) and provides a route of ascent from the intestinal tract to the CNS. This route bypasses TeNT's normal preferential binding sites in the spinal cord, and therefore the symptoms of a typical tetanus infection are not evident. Once in the brain, TeNT disrupts the release of neurotransmitters by the proteolytic cleavage of synaptobrevin, a synaptic vesicle membrane protein. This inhibition of neurotransmitter release would explain a wide variety of behavioral deficits apparent in autism. Lab animals injected in the brain with TeNT have exhibited many of these behaviors.
    http://www.ncbi.nlm.nih.gov/pubmed/9881820

    http://www.sb277.org/vaccines-and-autism.html
    An FDA report from 2005 titled “Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Tripedia” outlines a number of adverse events reported during post-approval use of the Tripedia vaccine, and one of them is autism. - http://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm101580.pdf

    Med Hypotheses. 1998 Aug;51(2):133-44.
    Autism and Clostridium tetani.
    Bolte ER.
    Autism is a severe developmental disability believed to have multiple etiologies. (...)
    The vagus nerve is capable of transporting tetanus neurotoxin (TeNT) and provides a route of ascent from the intestinal tract to the CNS. This route bypasses TeNT's normal preferential binding sites in the spinal cord, and therefore the symptoms of a typical tetanus infection are not evident. Once in the brain, TeNT disrupts the release of neurotransmitters by the proteolytic cleavage of synaptobrevin, a synaptic vesicle membrane protein. This inhibition of neurotransmitter release would explain a wide variety of behavioral deficits apparent in autism. Lab animals injected in the brain with TeNT have exhibited many of these behaviors.
    http://www.ncbi.nlm.nih.gov/pubmed/9881820
     
    Last edited: Jan 21, 2016
  2. roller

    roller wiggle jiggle

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    By the process of omission,

    biotin, folic acid, pyridoxamine, nicotinic acid, calcium pantothenate, uracil, and tryptophane were found essential,
    and
    riboflavin, vitamin B12, p-aminobenzoic acid, oleate, xanthine, guanine, and cystine were found nonessential and nonstimulatory to growth of the tetanus strains.

    Thiamin and inositol were nonessential but enhanced the growth of somestrains.

    The need for adenine varied with the strain and the medium from essential or stimulatory to nonessential.

    http://aem.asm.org/content/6/5/311.full.pdf
     
  3. barbc56

    barbc56 Senior Member

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    Is there even a condition called late stage tetanus? I think if untreated you'd be dead but I'm not a medical professional.

    Edit. According to this source mortality can vary from 10% to 60%. However, many factors determine this. For infants it looks like it's almost always fatal.

    It looks like you're concerned about the adverse event of autism that's listed? The CDC has to list all the adverse incidents reports they get whether founded or not.

    https://vaers.hhs.gov/data/index

    I may have missed your point.

    Barb
     
    Last edited: Jan 22, 2016
    roller likes this.
  4. Jonathan Edwards

    Jonathan Edwards Senior Member

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    I think you may be muddling tetanus infection with tetanus vaccine. I don't think there is neuroinflammation in either case. The toxin damages nerves but not through an inflammatory process. And for both infection and vaccination any toxin or toxoid would be gone within days. I don't think there is any chronic state.
     
    Valentijn and roller like this.
  5. roller

    roller wiggle jiggle

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    @Jonathan Edwards

    Many thanks for the reply.

    sounds like a bad CNS inflammation nobody would ever be able to diagnose?

    :whistle:
     
  6. roller

    roller wiggle jiggle

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    Most of us will have the tetanus bacteria.

    In some it may have broken out at some point - more or less severe - and it will have left its damages/footprints.

    @Jonathan Edwards
    What would would be the best option to check for a past or ongoing infection, flare up, damage?
    There must be one?

    All suggestions are much appreciated.
     
    Last edited: Jan 22, 2016
  7. roller

    roller wiggle jiggle

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    it is usually found in the gut.
    no problem.

    however, it becomes a problem when it leaks out.

    :sluggish:
     
  8. roller

    roller wiggle jiggle

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    http://www.ncbi.nlm.nih.gov/pubmed/25769344
     

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