OK, I've been holding off posting anything on this just in case I'm the only one having this problem (you know, the sound of tumbleweed blowing as everyone else shuffles out of the room embarassed). But, having seen this symptom listed on the XMRV+ questionnaire I'm feeling a little more emboldened. Since the onset of illness, I've become less and less tolerant of the feeling of pressure of clothes on my body, particularly around the waist (not related to any weight gain). As a healthy kid I was always sensitive to the feel of certain fabrics (wool primarily) but nothing of this nature. I can't stand any feelings of tightness, around the waist, wrists, collar etc and (ahem) underwear is the worst.:ashamed: At times the irritation drives me crazy and Mrs Marco is getting a little fed up with my baggy faded underwear. I've noticed clothes sensitivity as an issue in autism and given the suggested links between XMRV, autism and ME/CFS, there may be something in it. Add to that the Drs Light studies on pain reception and findings that people with IBS are more sensitive to gut pressure than controls. Please tell me I'm not the only one.