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Lessons from ME/CFS: Finding Meaning in the Suffering
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Clonidine lower noradrenaline decrease anxiety

Discussion in 'General Treatment' started by heapsreal, Nov 8, 2011.

  1. Valentijn

    Valentijn Activity Level: 3

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    It might not be safe to assume high norepinephrine is causing your anxiety or other problems. In my case, norepinehprine is very low - and effectively raising it (with an SNRI) helps a lot with my symptoms.
  2. Gypsy

    Gypsy Senior Member

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    Thanks Valentijn. My Clonidine experiment is definitely over! I was wondering about my reaction to amitryptypline. It was prescribed for sleep, but kept me wide awake (10mgs). It was like adrenaline city, major stimulant type effect. So I am wondering what would happen if I tried a very low dose of amitryptyple in the mornings, such as 5mg? I can only assume it increase norephinephrine, and maybe I need more. My only reservation is, all Antidepressants I have tried have only worsened my sleep, including Effexor, which is an SNRI, and Prozac, plus a few others, I think Zoloft. This was years ago. Plus all the AD's which are supposed to help with sleep, do not help me at all. I have become VERY reluctant to mess with my brain chemistry, so I am torn. I feel like possibly ultra LOW doses of certain "brain" meds could help us, but it always seems to become an experiment we as patients have to undertake on our own.
  3. Valentijn

    Valentijn Activity Level: 3

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    I don't know if it's that simple. Amitriptyline does have some effect on norepinephrine, but it also has a (bigger) effect on serotonin. My personal experience has been that I need to be REALLY careful with anything affecting serotonin, even though I'm deficient in that too.

    I think some people take an NRI and SSRI separately so doses can be adjusted independently of each other. Or there might be an SNRI that has just the right combination of action on each area :p Amitriptyline was a complete suck-fest for me. Didn't help with anything and made my ME symptoms worse, the same effect I get from other serotonin-increasing supplements.
  4. Gypsy

    Gypsy Senior Member

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    Really? See this is why we need our own personal pharmacologist to explain what meds do what and at what dosages! It is too difficult to figure it all out. Prozac, which definitely affects serotonin, turned me into an emotionless zombie. The amitryptyline also increased me heartrate (pretty common I guess?) so who knows where the stimulating effects came from. I just politely declined a prescription for Cymbalta for sleep. What!? Can someone explain how that would even possibly help with sleep?
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  5. Valentijn

    Valentijn Activity Level: 3

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    That is a bit weird ... it hasn't been used for sleep that I know of. Maybe if pain or anxiety is keeping someone awake? It can cause somnolence as a side effect, but it can also cause insomnia :p
  6. Lotus97

    Lotus97 Senior Member

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    SSRIs interfere with my sleep also, but they're the only thing that works for my depression.:confused: Thankfully, amitryptiline helps me sleep. I thought norepinephrine was a problem for me (and maybe it is), but I guess amitryptiline doesn't have a stimulating effect on me.
  7. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Hi Lotus97

    Do you take both an SSRI and amitryptiline? I thought this was a dangerous combinations.

    Best,
    Sushi
  8. Lotus97

    Lotus97 Senior Member

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    I take an SSRI for depression and amitryptiline for sleep. Are you talking about serotonin syndrome?
  9. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Yes, that is the usual reason for warning people not to take them together.

    Sushi
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  10. taniaaust1

    taniaaust1 Senior Member

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    Im glad this old thread has come up cause I never updated my post on it here. I did end up going onto Clonidine (for the kind of POTS I had) and for me this drug turned out great for my sleep even thou I didnt seem to have anxiety affecting it (but as I said I did have extremely high noradrenaline on my blood test results).

    Im now off of benzos, melatonin and doxylamine succinate combo I used to take for sleep and on this far safer drug.

    If you have high adrenaline showing up on your tests or swinging BP (going both low and high) do consider this drug for your sleep issues as it could help several things at once.

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