Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

[Sushi]

From CNN:
Breakthrough in cancer research could spawn new treatments

Researchers discovered that even though cancer cells mutate wildly within a person's body, the cancer cells within each patient also have common mutations -- ones that could be isolated and fought off by certain immune cells.

From ScienceMag:
Abstract

As tumors grow they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intra-tumor heterogeneity (ITH) on anti-tumor immunity....
These data suggest that neoantigen heterogeneity may influence immune surveillance and support therapeutic developments targeting clonal neoantigens.