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Clock-Dependent NAD+ Synthesis Controls Mitochondrial Metabolism

Discussion in 'Other Health News and Research' started by anne_likes_red, Sep 19, 2013.

  1. anne_likes_red

    anne_likes_red Senior Member

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    This article is reporting on a mouse study: Clock-Dependent NAD+ Synthesis Controls Mitochondrial Metabolism.
    ...Possibly interesting to those interested in a circadian tie-in to mitochondria, or anyone researching the SIRT pathways. :)

    nandixon and alex3619 like this.
  2. alex3619

    alex3619 Senior Member

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    NAD has been discussed a fair bit on these forums.
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  3. dannybex

    dannybex Senior Member

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    "Mitochondria regulate the supply of energy to cells when we are at rest, with no glucose available from food."

    I don't get it. Wouldn't there be glucose available if one has sufficient stores of glycogen?
  4. anne_likes_red

    anne_likes_red Senior Member

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    Heh yes but presumably they're talking about "fasting" (overnight for example) when it is available from glycogen - as opposed to directly after a meal.
    Fasting stimulates the sirtuin pathways (same as exercise, cold exposure and some other things like resveratrol....certain wavelengths of light too I think).
    No doubt the actual study will be worded more precisely than that article! :)
    dannybex likes this.
  5. alex3619

    alex3619 Senior Member

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  6. alex3619

    alex3619 Senior Member

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    The point of the article is that without proper activation the mitochondria go into power saving mode, I think. Its not about glucose being available, its about the furnace being shut down.

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