Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Clinical Value of Serum Neuroplasticity Mediators in Identifying the Central Sensitivity Syndrome...

Discussion in 'Latest ME/CFS Research' started by MikeJackmin, Jan 6, 2015.

  1. MikeJackmin

    MikeJackmin Senior Member

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    Clinical Value of Serum Neuroplasticity Mediators in Identifying the Central Sensitivity Syndrome in Patients with Chronic Pain with and Without Structural Pathology.


    Abstract


    Background and Objectives: Central sensitivity syndrome (CSS) encompasses disorders with overlapping symptoms in a spectrum of structural pathology from persistent somatic nociception [e.g. Osteoarthritis (OA)] to absence of tissue injury such as in fibromyalgia, chronic tension-type headache (CTTH), and myofascial pain syndrome (MPS). Likewise, the spectrum of the neuroplasticity mediators associated with CSS might present a pattern of clinical utility.


    Methods: We studied the brain-derived neurotrophic factor (BDNF), tumor necrosis factor alpha (TNF-[alpha]), and interleukins 6 (IL-6) and 10 (IL-10) in female patients with CSS absent of structural pathology (CTTH (n=30), MPS (n=29), fibromyalgia (n=22)); with CSS due to persistent somatic/visceral nociception (OA (n=27), endometriosis (n=32)); and in healthy controls (n=37).


    Results: Patients with CSS absent of structural pathology presented higher serum TNF-[alpha] (28.61+/-12.74 pg/mL) and BDNF (49.87+/-31.86 ng/mL) than those with persistent somatic/visceral nociception (TNF-[alpha]=17.35+/-7.38 pg/mL; BDNF=20.44+/-8.30 ng/mL), and controls (TNF-[alpha]=21.41+/-5.74 pg/mL, BDNF=14.09+/-11.80 ng/mL). Moreover, CSS patients absent of structural pathology presented lower interleukin levels. Receiver operator characteristics (ROC) analysis showed the ability of BDNF to screen CSS (irrespective of the presence of structural pathology) from healthy controls [cutoff=13.31 ng/mL, AUC=0.86, sensitivity=95.06%, specificity=56.76%]; and its ability to identify persistent nociception in CSS patients when experiencing moderate-severe depressive symptoms (AUC=0.81, cutoff=42.83 ng/mL, sensitivity=56.80%, specificity=100%). When the level of pain measured on the visual analog scale was <5 and moderate-severe depressive symptoms were observed TNF-[alpha] discriminated structural pathology in the chronic pain conditions (AUC=0.97, cutoff=22.11 pg/mL, sensitivity=90%, specificity=91.3%).


    Conclusions: Neuroplasticity mediators could play a role as screening tools for pain clinicians, and as validation of the complex and diffuse symptoms of these patients.


    (C) 2014 by Lippincott Williams & Wilkins

    http://journals.lww.com/clinicalpai...of_Serum_Neuroplasticity_Mediators.99351.aspx
     
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