Clinical Trials: testing viral load vs immune markers Dr. Yes wrote this: "The difference between Coffin's approach and Mikovits' is the choice of parameter. Coffin wants to wait til we can accurately monitor viral load, while Mikovits wants to monitor other parameters for which there is already evidence of correlations with symptomology in ME/CFS. A great many clinical trials have been done in a great variety of diseases with no known causative agent; the parameters in these cases are usually clinical ones like those Mikovits suggested, and have sometimes been as simple as functional improvement -- usually with some form of objective measure, of course." great quote! question: does anyone know what immune markers we'd use in a clinical trial, to gage efficacy of a treatment? something solid so that it can be used instead of viral load.