I developed severe dry eyes (keratoconjunctivitis sicca) in my first year of ME. Regular eyedrops and ointments did not help so the opthalmologist prescribed me ciclosporin 0.05% eyesdrops, brandname restasis. After a few days i noticed a drop in bodywide inflammation and my brainfog lifted somewhat. I was afraid of the possible side effects so ceased taking it. Ciclosporin decreases the function of T-cells and it also has an effect on mitochondria. I know a 0.05% dose is very low, but i'm very sensitive to medication, even topical preperations usually have a systemic effect on me. So, might ciclosporin in theory be efficient in ME? I've also been diagnosed with a Crohns-like disease which ciclosporin is sometimes used for.