Hi all, After asking a few patients from Dr Bieger about their results, it seems that while many are negative to EBV and XMRV according to a genetic expression profile most of them have increased values for unspecific viral immune activation. Dr Bieger told me that he does not know which virus is causing this but he is in favor of treating his patients with antivirals directed against herpes viruses. The question I ask myself and the question that I find so annoying is: Under what circumstances will a normal human body not be able to rid itself from a virus e.g. flu-virus or put in other words, is it possible that a human body suffers from chronic flu infection? I'm a complete layman but would it be possible that the human body tries to clear a virus but is stuck and fails to do so? Imagine a plane that tries to start but cannot move because someone forgot to remove the big brake pads. The pilot will increase thrust but the plane doesn't move while at the same time it will use a lot of fuel for nothing. The body directs its immune system towards the virus but something goes wrong so that the virus cannot be cleared but the immune system keeps being ramped up. Under this condition I can imagine that the activated immune system over time wears down the human body and causes all kinds of syptoms we encounter with CFS. I know that EBV, XMRV etc. could be a cause of CFS but what if we all suffer from a misguided immune system that for whatever reason fails to clear a certain viruses (may it be XMRV, EBV, HHV6, flu virus or whatever)? Would this be possible?