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Chronic-Infection-H-pylori-Manganese-Connection

Discussion in 'General ME/CFS Discussion' started by Radio, Jan 13, 2014.

  1. Radio

    Radio *****

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    H-pylori-Manganese-Connection?

    H-pylroi can block the absorption minerals and neutralizing stomach acids. The body has a preference for minerals. For example, the body prefers Zinc for over 50 critical enzymes. However, if Zinc becomes deficient (which is very common) or exposure to Cadmium, Lead or Mercury is sufficiently high, the body will use these toxic minerals in place of Zinc. When H. pylori infection decided to make a home in your body, it needs certain materials to do that. It needs to neutralize acid. It needs certain vitamins (B-12 is one of them). It needs to make enzymes to help keep it alive – its enzymes use up manganese- leaving the body deficient in manganese. Manganese is needed to fight free radicals. Without it cell membranes and the DNA are damaged. - See more at: http://www.mygutsy.com/is-h-pylori-...sorders-adrenal-fatigue/#sthash.1KzwEYym.dpuf

    Manganese superoxide dismutase (MnSOD) is the principal antioxidant enzyme in the mitochondria. Because mitochondria consume over 90% of the oxygen used by cells, they are especially vulnerable to oxidative stress. The superoxide radical is one of the reactive oxygen species produced in mitochondria during ATP synthesis. MnSOD catalyzes the conversion of superoxide radicals to hydrogen peroxide, which can be reduced to water by other antioxidant enzymes.

    Repairing the mitochondria, we allow our cells to increase their nutrient uptake so that supplementation support will have the most dramatic effect.

    A number of manganese-activated enzymes play important roles in the metabolism of carbohydrates, amino acids, and cholesterol (4). Pyruvate carboxylase, a manganese-containing enzyme, and phosphoenolpyruvate carboxykinase (PEPCK), a manganese-activated enzyme, are critical in gluconeogenesis— the production of glucose from non-carbohydrate precursors. Arginase, another manganese-containing enzyme, is required by the liver for the urea cycle, a process that detoxifies ammonia generated during amino acid metabolism (3). In the brain, the manganese-activated enzyme, glutamine synthetase, converts the amino acid glutamate to glutamine. Glutamate is an excitotoxic neurotransmitter and a precursor to an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA).

    Helicobacter Pylori: Not Just A Third World Problem?
    http://www.stopthethyroidmadness.com/h-pylori/

    Manganese is the preferred cofactor of enzymes called Glycosyltransferases

    http://lpi.oregonstate.edu/infocenter/minerals/manganese/

    CFS - can be caused by chronic infection
    http://www.drmyhill.co.uk/wiki/CFS_-_can_be_caused_by_chronic_infection
    Last edited: Jan 14, 2014
    helen1 likes this.
  2. alex3619

    alex3619 Senior Member

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    The manganese connection goes back to the late 90s in CFS I think. A guy called Stephen Coote used to have a website about it. He found many patients improved a lot with just manganese. Many don't though.
    Radio likes this.
  3. Radio

    Radio *****

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    Manganese deficiency has been observed in a number of animal species. Signs of manganese deficiency include impaired growth, impaired reproductive function, skeletal abnormalities, impaired glucose tolerance, and altered carbohydrate and lipid metabolism. In humans, demonstration of a manganese deficiency syndrome has been less clear (2, 7). A child on long-term total parenteral nutrition (TPN) lacking manganese developed bone demineralization and impaired growth that were corrected by manganese supplementation (17). Young men who were fed a low-manganese diet developed decreased serum cholesterol levels and a transient skin rash (18). Blood calcium, phosphorus, and alkaline phosphatase levels were also elevated, which may indicate increased bone remodeling as a consequence of insufficient dietary manganese.

    Manganese activates enzymes the play important role in the metabolism of carbohydrates, ammino acids, and cholesterol. Pyruvate carboxylase, a manganese containing enzyme, and phosphoenolpyruvate carboxykinase. Manganese activated enzyme, are critical in gluconeogenesis-the production of glucose from non carbohydrate precusors. Glucose is a 6 carbon sugar which plays a major role in the generation of energy for living organisms.
    Last edited: Jan 14, 2014
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  4. Radio

    Radio *****

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    RICH VAN KONYNENBURG

    "Partial blocking of the Mn-SOD gene means that your cells will not be able to make enough of the manganese superoxide dismutase enzyme. This enzyme is needed by the mitochondria to convert superoxide (oxidizing free radicals that are generated in the normal metabolism of the mitochondria) into hydrogen peroxide. The hydrogen peroxide is then normally dealt with by glutathione, together with the glutathione peroxidase enzyme, and is converted into water. Without enough Mn-SOD, your cells will suffer from oxidative stress."
  5. knackers323

    knackers323 Senior Member

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    What form of manganese would be best to try?
    What did Stephen Coote use?
  6. Radio

    Radio *****

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    Hi, I would look into Dr Myhill's work and see what she recommends. Manganese can be very toxic and need to be monitored at therapeutic doses.
    Last edited: Jan 14, 2014
  7. Radio

    Radio *****

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    Manganese Dietary Sources
    Rich dietary sources of manganese include nuts and seeds, wheat germ and whole grains (including unrefined cereals, buckwheat, brown rice, and oats), legumes, and pineapples.

    Available Forms
    Manganese is available in a wide variety of forms, including manganese salts (sulfate and gluconate) and manganese chelates (aspartate, picolinate, fumarate, malate, succinate, citrate, and amino acid chelate). Manganese supplements can be taken as tablets or capsules, usually along with other vitamins and minerals in the form of a multivitamin.

    How to Take It
    The daily Adequate Intake (AI) for manganese is listed below.

    Supplements and dietary intake of manganese together should not exceed 10 milligrams per day because of the risk of nervous system side effects. You should only take manganese supplements under the supervision of your doctor; that is especially true for children.

    Children and Infants

    • Infants 0 - 6 months: 0.003 mg
    • Infants 7 months - 1 year: 0.6 mg
    • Children 1 - 3 years: 1.2 mg
    • Children 4 - 8 years: 1.5 mg
    • Males 9 - 13 years: 1.9 mg
    • Males 14 - 18 years: 2.2 mg
    • Females 9 - 18 years: 1.6 mg
    Adult

    • Males 19 years and older: 2.3 mg
    • Females 19 years and older: 1.8 mg
    • Pregnant women: 2 mg
    • Breastfeeding women: 2.6 mg
    Pregnant women and nursing mothers should avoid intakes of manganese above the upper limit of the AI, unless under a doctor's supervision.

    Precautions
    Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider. The amount of manganese ingested in 1 day (from foods or supplements) should not exceed 10 milligrams due to the potential for nervous system damage.

    Calcium, phosphorous, and manganese work closely together in the body. For this reason, you may need more manganese if you are getting more calcium and phosphorus.

    Manganese rarely causes side effects when taken orally. It can be toxic to people who regularly inhale manganese vapors, such as industrial workers in steel mills and mines, or people with liver damage, including alcoholic cirrhosis. Symptoms include loss of appetite, headaches, leg cramps, muscle rigidity, tremors, convulsions, extreme irritability, acts of violence, and hallucinations. Manganese toxicity has also been seen in people who received very high amounts of intravenous nutrition (containing manganese) over long periods of time.

    Possible Interactions
    If you are currently being treated with any of the following medications, you should not use manganese supplements without first talking to your health care provider.

    Haloperidol and other antipsychotics -- There has been at least one clinical report of an interaction between haloperidol and manganese that resulted in hallucinations and behavioral changes in a person with liver disease. In addition, some experts believe that medications for schizophrenia and other forms of psychosis may worsen side effects from manganese supplements. If you take antipsychotic medications, do not take manganese without first talking to your doctor.

    Reserpine -- Reserpine, a medication used to treat high blood pressure, may lower manganese levels in the body.

    Antacids -- Magnesium containing antacids may decrease the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking antacids.

    Laxatives -- Magnesium containing laxatives may decrease the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking laxatives.

    Tetracycline antibiotics -- These drugs may reduce the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking these antibiotics. They include tetracycline, minocycline (Minocin), and demeclocycline (Declomycin).

    Quinolone Antibiotics -- Manganese may inhibit the body's absorption of these medications.

    Moenimycin -- Used in animal feed as a growth promoter
    Last edited: Jan 15, 2014
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  8. Hanna

    Hanna Senior Member

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    Jerusalem, Israel
    Dr Myhill recommended to me (in 2010) taking BioCare Nutrisorb Manganese (it is manganese ascorbate in drops) if it may help...
  9. Radio

    Radio *****

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  10. Radio

    Radio *****

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    Metabolism of common monosaccharides and related reactions


    [​IMG]
  11. Radio

    Radio *****

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    I'm studying Metabolism of monosaccharide and related reactions. It's my impression that Magnesium/Manganese/NAD+ deficiency can dramatically affect this metabolism.
    Last edited: Jan 20, 2014
  12. Radio

    Radio *****

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    [​IMG]

    Ribose Metabolism main co-factor is NAD+ / Niacinamide...
    Several metabolic routes allow NAD+ synthesis from four different precursors (blue box). In the de novo pathway, NAD+ is synthesized from L-tryptophan, which is converted to quinolinic acid (not shown) and then to nicotinic acid mononucleotide (NaMN). An import pathway originates with nicotinic acid (Na), which is converted to NaMN (through the Preiss–Handler pathway), nicotinic acid adenine dinucleotide and then NAD+. A salvage pathway uses nicotinamide (Nam) to regenerate NAD+(Refs 1, 2). Na and Nam are collectively referred to as niacin, or vitamin B3. A fourth, recently discovered route incorporates nicotinamide riboside in the salvage pathway106. NAD+ and its phosphorylated relative NADP (not shown) are used as cofactors in several different redox reactions that are catalysed by NAD+ dehydrogenases (yellow box). These reactions are not accompanied by any net consumption of the nucleotides. Conversely, a net loss of NAD+ is associated with ADP-ribose-transfer reactions that take place during ADP-ribose cyclization (orange box), mono- or poly(ADP-ribosyl)ation and the deacetylation of proteins (green boxes). All these ADP-ribose-transfer reactions link NAD+ metabolism and the energy status of the cell to various aspects of cellular signalling for different cellular functions. Free ADP-ribose or derivative molecules can result from poly(ADP-ribose) degradation, which is catalysed by PARG isoforms and hydrolases (ARHs; ADP-ribosylarginine hydrolases), or from O-acetyl-ADP-ribose hydrolysis by Nudix O-acetyl-ADP-ribose hydrolase. These molecules might participate in the activation of TRPM2 channels (which are involved in calcium entry)107 and might react with proteins (resulting in glycation), which can lead to severe endothelial dysfunction, as in the case of diabetes-mellitus-associated atherosclerosis and other cardiovascular diseases.

    [​IMG]

    NaDS, NAD+ synthase; NaMNAT, nicotinic acid mononucleotide adenylyltransferase; Nampt, nicotinamide phosphoribosyl transferase; NaPRTase, nicotinic acid phosphoribosyltranferase; NMNAT, nicotinamide mononucleotide adenylyltransferase; Nrk1, nicotinamide riboside kinase-1; PARG, poly(ADP-ribose) glycohydrolase; PARP, poly(ADP-ribose) polymerase.

    Last edited: Jan 16, 2014
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  13. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Wow! Wish I had time and brainpower to read all that!

    Do you have any views on d-ribose? Some people report benefiting from it, but I'm one of those who can't tolerate it.
    Radio likes this.
  14. Radio

    Radio *****

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    Hi, D-ribose can create a-lot of oxidative stress in the body and possibly trigger mast-cell activation. Also, We need to have a functioning superoxide dismutase enzyme for d-ribose to be effective. I can't tolerate D-Ribose either..But, I'm having very good results with eating non-enriched organic white/brown rice.
    Last edited: Jan 17, 2014
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  15. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    What do you mean by non-enriched?
  16. Radio

    Radio *****

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    No added....Vitamins or additives...No fortified foods....Just plan rice...Just eat real food...:thumbsup:
  17. brenda

    brenda Senior Member

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    They add vitamins to some rice in the US. I think organic is safe there. They don't do that here.
  18. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    How on earth do they enrich rice?! :confused: Is this cooked rice, perhaps? I can't see how uncooked rice could be enriched unless it's genetically modified!
  19. brenda

    brenda Senior Member

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    No idea I'm afraid.
  20. Leopardtail

    Leopardtail Senior Member

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    Sorry to hear it did not work for you Radio, was like a magic bullet for me. What is non-enriched rice though? Am curious as a big cat.

    As for the SOD surely that would apply to all measures that restore normal (oxidative) energy generation? At the end of the day all of AMP, ADP, ATP required ribose its a component part whether supplementary or made my the body. The objective here is to create whole new molecules, not to use Ribose as a direct energy source (though the body will clearly do that whether we like it or not).
    Last edited: Jan 19, 2014
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