Chronic fatigue traced to mitochondria, Robyn Williams interviews Professor Warren Tate

[Barry53]

http://www.abc.net.au/radionational...hronic-fatigue-traced-to-mitochondria/8521808

As our energy is the result of cellular processes within mitochondria, it is here Warren Tate at Otago University in Dunedin is looking for clues. He says new technology allows researchers to see molecular changes before and after exercise. And there is excitement as one enzyme, key to the chemical processes appears to be defective in patients with chronic fatigue. Whilst it is certainly early days, these promising results may allow researchers to hone in on an explanation for the fatigue condition which paralyses the lives of some patients.

Interesting NZ interview.

 

[Snowdrop]

Excellent.

 

[RogerBlack]

Published on Jul 25, 2015
Professor Tate has a daughter who suffers from ME/CFS. As an award winning biomedical researcher, and close family member of a sufferer, Warren provides an invaluable perspective on the illness.

http://biochem.otago.ac.nz/our-people/academic-teaching-staff/warren-tate/

We have developed a simple recombinant production and purification strategy for a processed brain protein, secreted amyloid precursor protein-alpha, a protein that is neuroprotective but whose concentration is lowered in Alzheimer’s patients. Remarkably, we have shown our recombinant protein alone can restore memory to rats impaired by drug treatment, not only in their electrophysiological responses but also in trials to determine memory of learned spatial tasks.

Interesting work.

 

[IThinkImTurningJapanese]

From 6:02 "There were other health professionals, who, from a platform of ignorance..."

 

[justy]

What a great news channel - they divide up the stories in the programme so we don't have to trawl through looking for it.

https://radio.abc.net.au/programitem/pgd6oPPdDV?play=true

 

[adreno]

Which enzyme is he talking about?

 

[slysaint]

@Janet Dafoe (Rose49) does any of this tie in with Rons research?

@Frustrated the video above might help your parents understand better.

 

[Eian Mcneely]

Interesting research, this can be a potential discovery. It doesn't mention of which particular enzymes.

 

[happy]

@adreno it seems to be PDHC.

From the transcript:
That is, it's what we call a tricarboxylic acid cycle or the TCA cycle, intermediates seemed to be lower and the enzyme which transitions the energy producing system into the final stage, pyruvate dehydrogenase complex, seems to be defective.

 

[Snowdrop]

If it is PDHC that is being referred to then this deficiency is known to medicine (as one that starts in childhood or infancy)

http://emedicine.medscape.com/article/948360-overview