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Chronic fatigue syndrome and idiopathic intracranial hypertension

Discussion in 'Latest ME/CFS Research' started by JaimeS, Aug 11, 2017.

  1. JaimeS

    JaimeS Senior Member

    Mid-Ohio Valley, United States
    Just saw this in medical hypotheses:

    Though not discussed in the medical literature or considered in clinical practice, there are similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) which ought to encourage exploration of a link between them. The cardinal symptoms of each – fatigue and headache – are common in the other and their multiple other symptoms are frequently seen in both. The single discriminating factor is raised intracranial pressure, evidenced in IIH usually by the sign of papilloedema, regarded as responsible for the visual symptoms which can lead to blindness. Some patients with IIH, however, do not have papilloedema and these patients may be clinically indistinguishable from patients with chronic fatigue syndrome. Yet IIH is rare, IIH without papilloedema (IIHWOP) seems rarer still, while chronic fatigue syndrome is common. So are the clinical parallels spurious or is there a way to reconcile these conflicting observations?

    We suggest that it is a quirk of clinical measurement that has created this discrepancy. Specifically, that the criteria put in place to define IIH have led to a failure to appreciate the existence, clinical significance or numerical importance of patients with lower level disturbances of intracranial pressure. We argue that this has led to a grossly implausible distortion of the epidemiology of IIH such that the milder form of the illness (IIHWOP) is seen as less common than the more severe and that this would be resolved by recognising a connection with chronic fatigue syndrome.

    We hypothesise, therefore, that IIH, IIHWOP, lesser forms of IIH and an undetermined proportion of chronic fatigue cases are all manifestations of the same disorder of intracranial pressure across a spectrum of disease severity, in which this subset of chronic fatigue syndrome would represent the most common and least severe and IIH the least common and most extreme.
    L'engle, MEMum, pattismith and 3 others like this.
  2. Valentijn

    Valentijn Senior Member

  3. kangaSue

    kangaSue Senior Member

    Brisbane, Australia
    I've seen it suggested that left renal vein compression (Renal Nutcracker Syndrome) can cause a slight increase in intracranial pressure so maybe that leads to intracranial hypertension too. It's certainly known to be a cause of POTS

    When the left renal vein is compressed, the blood flow from the kidney that usually drains into the inferior vena cava can reflux into the spinal canal to cause the increased intracranial pressure, something called midline congestion syndrome I think.
    L'engle and ScottTriGuy like this.
  4. Matthew Jones

    Matthew Jones Senior Member

    Two of the researchers of this study have tried treatments for this on me. I had a lumber puncture, and I felt better for a few days after that. They said that this suggests I have brain inflammation as the drained cerebral spinal fluid creates more space for the brain. But there was no way to make the effects permanent.

    They also did a jugular venoplasty on me, because scans showed there was a slight narrowing of my veins. This is where they insert balloons inside the vein to make it widen to increase blood flow. The first time they did it I thought I felt a mild improvement but felt nothing the second time.

    In the end we gave up though I was left with the offer of having a neck stent put in. I decided not to having not fet enough improvement from the venoplasties.

    I'm lucky they tried it out on me but unfortunately it didn't work.
    L'engle and ScottTriGuy like this.

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