http://reference.medscape.com/viewarticle/873970 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (January 21-27): Chronic Fatigue Syndrome An investigation into the origins of a sometimes controversial condition is responsible for this week's top search term. A new study suggests that the blockage of a metabolic enzyme could be responsible for the symptoms experienced in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). The findings suggest a reduction in the amino acids that fuel oxidative metabolism could result in a shortage of energy in muscles and a buildup of lactate. This may have major implications in understanding and treating a challenging condition, leading to the popularity of this week's top term.