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Chronic Coxsackievirus B Infection Eliminated by Transfer of B Cells From Immune Mice

Discussion in 'Latest ME/CFS Research' started by Hip, Oct 6, 2013.

  1. Hip

    Hip Senior Member

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    Mice that do not have B cells (B cell knockout mice) with lifelong persistent coxsackievirus B (CVB) infection were injected with B cells from mice that are immune to CVB, and this resulted in either a transient or permanent disappearance of detectable CVB in the infected mice.

    The injected B cells resulted in a permanent elimination of the coxsackievirus B infection in a few of the mice.

    See the paper: The role of B lymphocytes in coxsackievirus B3 infection

    This paper is not new (published in 1999), but this info would seem pertinent for enterovirus-associated ME/CFS.

    It raises the obvious question of whether a similar technique could be used to eliminate, once and for all, the coxsackievirus B infections that are thought to be a major cause of ME/CFS.
     
    Last edited: May 28, 2015
  2. Little Bluestem

    Little Bluestem Senescent on the Illinois Prairie ❀❤✿Ƹ̵̡Ӝ̵̨̄Ʒ✿❤❀

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  3. globalpilot

    globalpilot Senior Member

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    Interesting. Did you see the study on Dr Chia's website showing interferon B elimated chronic coxsackie in the heart in humans ? Anyone idea how this information ties in with that ?
     
  4. alex3619

    alex3619 Senior Member

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    This is similar to the cure for HIV. It works for HIV, another immune cell pathogen (T cells in this case).

    Since I am CVB+ I am interested in this. Thanks Hip.
     
    merylg likes this.
  5. Hip

    Hip Senior Member

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    @Jonathan Edwards

    Might the study (this one) cited at the start of this thread have any relevance to rituximab treatment of ME/CFS?

    Chronic coxsackievirus B (CVB) infection is strongly associated with ME/CFS, and when mice with chronic CVB infection were injected with B cells taken from mice immune to CVB, this resulted in either a transient or permanent disappearance of detectable CVB in the infected mice.

    This suggests that there may be something amiss with the B cells of those susceptible to CVB, that allows the infection to become chronic, rather than being cleared by the immune system.

    Indeed, the authors found that in the mice with chronic CVB infection, approximately 1 to 10% of the B cells were infected with CVB, and the authors suggest the possibility that these CVB-infected B cells may play some role in virus dissemination, and/or that by infecting these B cells the virus may be able to modulate the host immune response.
     
    Last edited: May 28, 2015
    snowathlete and merylg like this.

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