Dr Zamboni looking into Epstein-Barr Virus. What about XMRV?! FYI another update from the MS forums. Note the mention below of "Endothelial Disrupters" (endothelial = the inner lining of blood vessels), specifically by Epstein Barr Virus. In other words, Dr Zamboni is looking at viruses that also are associated with ME/CFS, that might affect narrowing of those veins draining the brain. (NOTE: Parvovirus B19 is another endothelial disrupter, as are HHV-6, cytomegalovirus, adenovirus, and enterovirus - all ME/CFS opportunistic viruses) Might virally-related CCSVI end up also falling under the XMRV umbrella? Interesting to consider the crossovers between XAND and MS/CCVSI.... If the latitude-influenced MS cases end up having XMRV/EBV causing swelling of those stenosed veins, that could be another "game-changer" for us - a whole other patient group (like prostate cancer pts) clamoring for XMRV testing and therapies. I would think that would be a good thing - strength in numbers, and synergy in major goals. Imagine if WPI's breakthrough doesn't just help us, but other patient groups in dire need? Very cool. From: http://www.thisisms.com/ftopict-9040.html "Dr. BB Lee addressed the geographic incidence question at the Bologna conference- he stated that venous malformations occur in Caucasians- who also happen to settle further from the equator. Also, women suffer from venous insufficiency at a higher rate than men. These are known, studied facts in relation to other venous diseases, but have not been written about in CCSVI, since we've only known of this pattern for a year. Dr. Zamboni's team is currently studying EBV and a variety of other external influences (smoking/fats/obesity/Lyme/Cpn) in endothelial disruption and exacerbation of stenosis and reflux. But there are no papers available today. Therein lies the problem, and the flights of fancy in the current speculation. We just don't have the research today (Check back tomorrow for the Liberation Procedure paper.)" Also: http://www.thisisms.com/ftopict-8691.html "Dr. Zamboni spoke recently in Bologna about "endothelial disrupters" such as Cpn, Epstein Barr, low vitamin D, toxins, heavy metals and smoking...all outside influences which can worsen a stenosis and exacerbate reflux. Maybe candida could be added to that list. There will be many studies in the coming years so...according to Dr. Zamboni's research, we see stenosis comes first, then reflux of blood into the brain (which can be exacerbated by endothelial disruption) which results in what we now call "MS." I can't help thinking that MS/CCSVI and XMRV/XAND researchers should be cross-pollinating their work. Imagine if we had the power of the MS advocacy groups behind us - to mutual benefit?! At the very least, somebody should point out the possibility to Dr Z that if he is looking at EBV, he should definitely also be considering the possibility of XMRV involvement. And so, good night!