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Chromosome 6

Discussion in 'Other Health News and Research' started by wastwater, Dec 31, 2015.

  1. wastwater

    wastwater Senior Member

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    Last edited: Jan 9, 2017
  2. wastwater

    wastwater Senior Member

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    I have a rare genetic disorder riegers syndrome and someone else who has it managed to get a whole genome scan,
    and only faults came back on chromosome 6,
    IRF4 was one gene that was mentioned
    AS I think riegers syndrome,for some,maybe 20 percent,seems to come with an immune problem very much like ME/cfs with fibromyalgia being the most common diagnosis
    This is what raised my interest
    For completeness the other genes were HUS1B FOXQ1/F2 and C1 plus GMDS that has something to do with NADP+
    FOXF2 blood brain barrier formation and other tissues
     
    Last edited: May 9, 2017
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  3. wastwater

    wastwater Senior Member

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    IRF4 (MUM1) is interferon regulatory factor 4 (T helper cells th2 th17 th9 )
    GMDS is GDP-manose 4,6-dehydratase ,I think this can be involved in congenital disorders of glycosylation,im not sure what glycosylation is but have seen it mentioned on PR
    might be involved in glucose and carbohydrate use
    human gdp-mannose 4,6-dehydratase polypeptide shares 61% identity with the enzyme from e coli, I wonder could the immune system cross react and target them both
     
    Last edited: May 9, 2017
  4. wastwater

    wastwater Senior Member

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    Found this paper in Oxford academic human molecular genetics
    FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A
     
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  5. wastwater

    wastwater Senior Member

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    I saw this on YouTube LOM612 and think it’s this Isothiazolonaphthoquinone
    Small molecule activator of FOXO
    And possibly methylselenic acid (selenium)
     

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