I understand from Yasko that choline and TMG promote the BHMT pathway and when your cellular levels of Folate, B12 and cofactors are sufficient that DMG slows the BHMT pathway and encourages the methionine synthase pathway which increases glutathione. My goal is to increase my glutathione levels, so after a couple months of Folate, MB12, AB12 & Cofactors, I added DMG. Great results from the DMG - more energy and feeling better overall. I had previously tried TMG and did not have any noticeable effects. However, for whatever reason (pcos, general imbalances, who knows), I cannot keep my appetite under control unless I take choline. Without choline, I never feel satiated or full no matter what I have eaten (my diet is very clean Paleo). I currently take about 3 grams of choline per day (1 g before each meal) and I take 1000 mg of DMG (500 mg twice a day) which gives me good results with my energy. I wonder if the 3g of choline vs the 1g of DMG is overdriving the BHMT pathway? Can't find any information what what dosage of DMG is needed to encourage the methionine synthase pathway over the BHMT pathway. Anyone have a clue about this?