I agree with parts of both of your posts Mij and Jarod. Methylation is important, but it isn't the only detoxification pathway, and perhaps that's why some haven't found benefit from the protocol, because they're only addressing one part? Just a thought... And personally, I would re-arrange the order on Jarod's list. I'm definitely not a scientist, and can barely think straight lately, but I just have a feeling the heavy metals/environmental toxins/chemical exposures, etc pile up first, overloading our liver, our HPA axis, our thyroids (?) and in general messing up our immune function, gut function and genetic expression -- so that when we need to deal with a virus, our immune system doesn't react appropriately, and so we stay sick. Maybe there are genetic factors that make us less able to detoxify particular toxins, but even Rich, in the last couple of years was saying that if one gets worse on the SMP or even Yasko, that heavy metals or mold, etc., may need to be addressed first. ??? Thanks for your replies.