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Chemotherapy and stem cell treatment successful in MS

Discussion in 'Other Health News and Research' started by Bob, Jun 9, 2016.

  1. Bob

    Bob

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    There are a heap of articles published about this today...

    This is the research paper...

    Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial
    Atkins HL et al.
    2016
    The Lancet.
    DOI: http://dx.doi.org/10.1016/S0140-6736(16)30169-6
     
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  2. Bob

    Bob

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  3. Sushi

    Sushi Senior Member Albuquerque

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    They keep publishing similar studies but the "prolonged period" may not be forever. My friend had this procedure and the prolonged period was 5 years....then he began regressing.
     
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  4. Justin30

    Justin30 Senior Member

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    I see think like cancer people will go into remission but can get it back......hopefully this works and becomes a viable option.

    I honestly think this will be a solution to Neuro ME patients at some point or the portion that Responds to Rituximab......

    I would honestly like to see mixed immune therapy followed by stem cells in this disease. Some of the new stem cells being developed can switch on and off genes...pretty amazing....
     
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  5. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    This will/should be, the last option, for relapsing ME-patients who have responded to immunosuppressive agents - in the future.
     
  6. Justin30

    Justin30 Senior Member

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    What about those with progressive ME for which no treatment works?

    For the severe I almost think that a boost with stem cells followed by a complete immune system wipe out then rebuild it again with clean stem cells. With all the talk coming out of the lastest conference it seems like ME is looking more autoimmune for the a greater # of people.

    We barely have effective treatments for AI diseases that currently exist.
     
  7. lansbergen

    lansbergen Senior Member

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    Mine was progressive and the immunemodulator I take slowly reversed it.
     
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  8. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Well one would need stronger indications for ME being possibly AI, than we have now. In sclerodermia clinical trials on SCT are ongoing, even though the underlying disease process is not completely understood. They do however know much more than we do with ME.
     
  9. Justin30

    Justin30 Senior Member

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    I agree...that being said many of those whos rituximab has been succeful for have had autoantibodies which I assume are autoimmune type antibodies. These individuals show ANA, Muscarinic, Acetylcholine, and other autoantibodies.

    What I have heard that stem cells can get a person with ME well enough to potentially with stand a treatment that wipes out their immune system.

    These are all just thoughts. I dont know if you have seen the article below:

    http://www.healthrising.org/blog/20...-progress-invest-me-chronic-fatigue-syndrome/
     
    ErdemX likes this.
  10. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    We are talking about the same thing, or? Stem cell transplant, not stem cell injection?
     
  11. justy

    justy Donate Advocate Demonstrate

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    YES - this is important. Lots of discussions on Lyme groups too about the usefulness of stem cells, and then people pointing to the MS research. The MS research is a stem cell transplant - a very risky and dangerous procedure. A friend of mine had it for aggressive rare cancer and it was a very big deal. She survived but now, post treatment has severe fatigue and may never be as well as she was pre cancer treatment.

    The type of stem cell treatment being talked about for Lyme etc is a stem cell injection - not a transplant (autologous or otherwise)
     
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  12. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Exactly. Patients with different types of marrow failure, typically also experience a range of very unpleasant side effects. Graft versus host disease etc. The field of BMT is however progressing rapidly, and will probably be a lot less dangerous in 10 years.
     
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  13. veganmua

    veganmua Senior Member

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    Thought this would be of interest here. Looks like a more thorough version of what Fluge and Mella are attempting with rituximab. Any idea if anyone can be persuaded to do a trial of this for M.E patients?

    http://www.ohri.ca/newsroom/newsstory.asp?ID=786
     
  14. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I think we already have a thread on this. I would not consider it for ME/CFS. This approach has been going for some twenty years and although it works people die (one in this study) from the treatment - about 4% in the past, maybe a bit less now. Busulphan and cyclophosphamide is a horrible cocktail to tolerate. Until we have some idea which bit of the immune system might need ablating in which patients it cannot be justified, as I see it. In the diseases where both have been tried (rituximab and high dose ablation with stem cell rescue), which is RA, MS, lupus and a few more, the results with the two treatments are not very different. Rituximab stops new episodes in MS completely, like this. It has not been developed for what look to me like commercial reasons. I strongly suspect that killing anything more than B cells is not needed. Rituximab may need repeating but at least that is easy enough. If relapse occurs after ablation with rescue repeating is probably not an option.
     
  15. Sushi

    Sushi Senior Member Albuquerque

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    NOTE: The two threads on this topic have been merged.
     
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  16. veganmua

    veganmua Senior Member

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    Thanks for your insight. I did check, but I must've missed the other thread!
     
  17. Justin30

    Justin30 Senior Member

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    Injection via spinal cord and intravenous
     
  18. Justin30

    Justin30 Senior Member

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    Without knowing what ME is...which I personally think is more than one disease....

    Using different approaches I feel is the future of ME especially when I feel it is likely different diseases.
     
  19. Sushi

    Sushi Senior Member Albuquerque

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    Quote from my friend who had this procedure:
     
  20. Justin30

    Justin30 Senior Member

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    70% response is huge
     
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