Hi Danny, I am interested in your experience with methylation, as like you, I am having a hard time tolerating methyl b12 and methyl folate. i go alright for a week or two and then i have incredible problems with ithing, nausea and headaches- just becomes intolerable and my doses are not that high. I know i react strongly to chlation of mercury as i have tried almost all the supplements that are meant to help, and have found tolerating any mercury chelation to be diffficult to sustain- it just makes all my pre existing symtpoms a lot worse. i am toying with the idea of trying chelation again too- andy cutler style. Have you tried the cutler protocl- and if so, what dose of dmsa could you tolerate. I did a day and a half about 8 months ago- i took divided doses of 3 mg and had to give up. I know it sounds pathetic but i was a couch ridden mess with all my symtpoms. I am thinking about trying again but at a lower dose of .75mg. I cannot understand why i react so badly at these doses , which as I understand it are baby doses. Maybe after doing methylation for 6 months i may find it less diffficult, but I am cautious, for good reason. Trouble is, some of us may not heal until the mercury is addressed, i am strating to come around to that idea, as 6 months on fredds protocol and I dont seem to be making more progress- some improvement in energy but otherwise lots of downside symptoms. I have stopped all my methylation supps at the moment and day 2 still feel bad with aches and pains, headaches nausea and itchy skin. I am hoping to find out my base off the supps and then maybe add them back but at a lower dose. Then...may need to bite the bullet and try mercury chelation again. i would be interested to know your experiences with meercury chelation so far? I tried ala once as a sustained release 300mg tablet and had extree headaches, so stopped.