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Characterization, Mapping and Distribution of the Two XMRV Parental Proviruses

Discussion in 'XMRV Research and Replication Studies' started by Jemal, Oct 27, 2011.

  1. Jemal

    Jemal Senior Member

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    http://jvi.asm.org/cgi/content/short/JVI.06022-11v1
     
  2. Bob

    Bob

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    England (south coast)
    Well, it's an interesting theory, and it seems plausible to a lay person (me).

    But I wonder if they've read the unpublished recombination paper that rebutts their previous and current conclusions:

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    Mattia C F Prosperi , William M Switzer, Walid Heneine and Marco Salemi
    6 June 2011
    Unpublished abstract presented to the '15th International Conference on Human Retroviruses: HTLV and Related Viruses'
    Retrovirology 2011, 8(Suppl 1):A235doi:10.1186/1742-4690-8-S1-A235
    http://www.retrovirology.com/content/8/S1/A235
    Conclusion:
    "Given the evidence of inter-tropic recombination in MuLV, detection and classification of recombination in XMRV using different MuLV tropism prototypes should be interpreted with caution ... These results suggest that identification of parental strains of the potential recombinants is difficult and that recombination in the highly genetically related MuLV have been occurring for some time."
     

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