Apparently people with anorexia have high leptin levels...hypothalamus dysfunction not sensing need to bring in more calories which is one type of resistance. Bulimic people have low leptin levels...and hypothalamus senses this as needing to bring in more calories. And obese people have high leptin levels again...and hypothalamus doesn't seem to respond to leptin signals at all which is a different type of resistance. What's interesting to me is that time and time again it comes back to the hypothalamus...where the nervous system and the endocrine system meet and communicate. Broken, again.