Hi, Real quick history. Diagnosed with CFS in '93 (shingles in '85 at age 32, and felt horrible after that for years), Lyme in '08, ERMI test results of 19.87/20 with "bad" gene for mold detox in '12 (expensive home remediation), and now just got back my 23 and Me test results. I was homozygous for ACAT which I keep reading is a #1 priority and frequently a problem for patients with CFS. Wish I knew how to print out my Genetic Genie results (cut and paste?), but here are my "reds" (both methylation and detox): VDR Bsm, ACAT1-02, CYP1A2 164A>C, CYP2D6 100C>T. My "yellows" are: COMT V158M, COMT H62H, MAO A R297R, MTR A2756G, MTRR A66G, AHCY-01, AHCY-02, AHCY-19, CBS A360A, CYP2C19*17, CYP2D6 S486T, CYP3A4*18, SOD2 A16V. The more I read, the more confused I get. My doctor is just learning about this-she is a functional doc and great, but can only know so much. I am wondering if I should just try the ACAT supplement from Yasko. My lyme doctor has me on a good supplement/probiotic routine and my functional doc. is tweaking it a bit from stool test results, etc. I stopped my lyme treatment when I got tired of hearing (after 5 years and IV) that everything was a herx or biofilms. Now I am wondering how much was the sulfur drugs and lousy detox. I keep looking at the position of that ACAT gene at the start of the methylation pathway and just think it has had a major role to play in YEARS of disabling fatigue. Anyone have the time to give me their two cents--I would SO appreciate it!