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CFS, Lyme, Mold, and now SNPs...help

Discussion in 'Genetic Testing and SNPs' started by Meremom, Jun 26, 2013.

  1. Meremom

    Meremom

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    Lexington, Virginia
    Hi, Real quick history. Diagnosed with CFS in '93 (shingles in '85 at age 32, and felt horrible after that for years), Lyme in '08, ERMI test results of 19.87/20 with "bad" gene for mold detox in '12 (expensive home remediation), and now just got back my 23 and Me test results. I was homozygous for ACAT which I keep reading is a #1 priority and frequently a problem for patients with CFS. Wish I knew how to print out my Genetic Genie results (cut and paste?), but here are my "reds" (both methylation and detox): VDR Bsm, ACAT1-02, CYP1A2 164A>C, CYP2D6 100C>T. My "yellows" are: COMT V158M, COMT H62H, MAO A R297R, MTR A2756G, MTRR A66G, AHCY-01, AHCY-02, AHCY-19, CBS A360A, CYP2C19*17, CYP2D6 S486T, CYP3A4*18, SOD2 A16V.
    The more I read, the more confused I get. My doctor is just learning about this-she is a functional doc and great, but can only know so much. I am wondering if I should just try the ACAT supplement from Yasko. My lyme doctor has me on a good supplement/probiotic routine and my functional doc. is tweaking it a bit from stool test results, etc. I stopped my lyme treatment when I got tired of hearing (after 5 years and IV) that everything was a herx or biofilms. Now I am wondering how much was the sulfur drugs and lousy detox. I keep looking at the position of that ACAT gene at the start of the methylation pathway and just think it has had a major role to play in YEARS of disabling fatigue. Anyone have the time to give me their two cents--I would SO appreciate it!
     
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  2. Valentijn

    Valentijn Activity Level: 3

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    Amersfoort, Netherlands
    The red VDR Bsm is actually the good version, and there's no research showing that the ACAT1-02 is at all relevant to the functioning of the gene. The AHCY SNPs are also lacking any support showing that they effect the AHCY gene. Same for CBS A360A.

    I haven't looked at the COMTs, MAOA, or MTRR A66G yet. Or the detox SNPs.

    But basically your methylation reds are actually one green and one irrelevant. The MTR and MTRR might have a small impact on your methylB12 formation, so supplementing some of that might help a bit. Or not :p
     
  3. Meremom

    Meremom

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    Lexington, Virginia
    Thanks. I have been trying to google ACAT +mutation etc. to find out if the mutation actually impacted the chain of events after it (excuse my simplistic thinking). I have not been able to find anything, as you say, that shows it is "at all relevant to the functioning of the gene." It certainly appears to sit in an important "gateway", but there is so much contradictory info out there and I have tried not to throw too much money down holes that aren't confirmed. I did have a positive Igenex lyme test or I'm not sure I would have gone on with all the lyme treatment. Thanks for your take on my SNPs. Right now I am focusing on a healthy diet and lifestyle.
     
  4. sianrecovery

    sianrecovery Senior Member

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    Manchester UK
    My yasko results weren't that bad, so I put off a methylation protocol for years, but I wish I hadn't, because I feel so much better on Rich's protocol. Sure - you can have or not have dodgy genes, but I would bet you can also get functional issues with methylation due to infection etc. I also have the 'dreaded' multisuspectible geno on mold and lyme - maybe that's why it seems to be helping so much.
     
  5. Meremom

    Meremom

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    Lexington, Virginia
    Sianrecovery, Thanks for your input. I am so new to the methylation protocol choices, could you elaborate on "Rich's protocol?" You don't have to type out what you take, just a link to his philosophy and suggestions would be helpful. I keep seeing the recommendation for bile salts for ACAT and a variety of other supplements (some of which I am on), but it is hard to know what to try. I read everything on CFS for many years, then it was toxic fish poisoning (which I had as a Peace Corps Vol. and which took me to Ritchie Shoemaker's site many years before I knew about mold or lyme), and in recent years I've read everything about lyme (abx, herbs, etc.) I can barely wrap my mind around trying something new, but this looks promising with my genetic results and my results from a methylation pathway test 2 years ago (that my doctor and I ignored--why she ran the test, I don't know...) Thanks for your help--I am sure, if you have responded to my message, that you have been down all these roads, too. Bless you and I hope your health is improving.
     
  6. caledonia

    caledonia

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    Cincinnati, OH, USA
    The thing that people seem to miss is yeah, you may have the SNP, but is it expressed? Yasko has detailed descriptions of what constitutes expression, both by testing and symptoms. http://www.dramyyasko.com/resources/autism-pathways-to-recovery/chapter-6/

    My sister is ACAT +/-, and has several ACAT symptoms, including kidney stones. It seemed pretty obvious in her case, so she didn't do testing. She's taking the Yasko ACAT/BHMT supplement as she has both of those mutations, and it's a cost effective all in one formula.

    You don't have any BHMTs, so I'm not sure if that formula would be suitable for you. That would be something to research, because otherwise, that means 8 or 9 separate supplements to address ACAT. I suggest asking about it on Yasko's forum.

    There are many other things that can cause fatigue - just from your SNPs, the MTR/MTRR combo is a bad one (I have that one too). It will cause great depletion of B12. SOD can also cause fatigue (got that one too). There is a supplement for SOD some of us have been discussing on here. http://www.agrigenic.com/xee.htm There was one patient who had significant improvement from it (no longer bedridden). I'm eyeing that one if my other efforts don't help significantly.

    I got a great deal of useful info from doing the Nutreval test. You can see your Krebs cycle and where the blocks are and what to do about them. Lead and mercury and various vitamin deficiencies are big culprits. Also mito supps can help the Krebs cycle. I'm getting a nice boost off of l-carnitine fumarate.

    My signature has what I consider the best links for methylation info.
     
  7. Meremom

    Meremom

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    Lexington, Virginia
    Caledonia, Thanks for jumping in. I had the NutraEval test run two years ago and, at the time, my doc and I had no idea why most of my "Bs" were so low (I was supplementing). She gave a talk on 23 and Me and Methylation pathway this Spring and a little light bulb went off in my head that all of it sounded familiar. So I just got out my NutraEval test and have been looking at it along with my Genetic Genie results. Thanks for your great work on the Interpretation Guide and for the other links. Looks like I've got some studying to do, but so much easier with some direction!
     

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