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CFS is a metabolic condition!

Discussion in 'General ME/CFS Discussion' started by Dr.Patient, Jun 18, 2014.

  1. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    And oddly, some of us have over-the-top NK cell function?!

    Sushi
    merylg and justy like this.
  2. Elph68

    Elph68 Senior Member

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    Hey Mellster, I am considering an accumulative effect .... What if it is an accumulation of these bacteria species having the same affect .... The body can handle 1 or 2 species but when hit with 4 or more species ... That tips it over and the damage is accelerated and uncontrollable .......

    Pathogenic normal flora .... The undetectable infection ...
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  3. Gingergrrl

    Gingergrrl Senior Member

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    @Elph68 I know this may be a complex question, but I don't understand what you mean by the undetectable infection. Even if someone had multiple infections (i.e. EBV, HHV-6 and five others) couldn't they all be detected by testing? Also, when you say "flora" does that mean in the mouth/throat or stomach or elsewhere?
  4. manna

    manna Senior Member

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    i was lookming into pneumonia and other infections a few years ago and was surprised to find out how difficult it was to even test for and diagnose some well known, and potentialy deadly, diseases. it seems that physical manifesations, and exclusion, are used to diagnose as much as lab tests showing infection...which, apparently, can be ambiguous at best.
  5. Elph68

    Elph68 Senior Member

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    Hi Ginger, an infection is an overgrowth of known pathogens. The undetectable infection is not necessarily an overgrowth, just having them there could be causing grief. They are undetectable because the pathologist classes them as normal flora so they are ignored. Flora is the bacteria found anywhere on the body including the skin, nose, throat, genitals, bowel etc.

    If you get 5 species of bacteria acting in the same way, then it is an infection, but it is undetectable, because the bacteria are considered harmless when they are on their own ......
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  6. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I don't recognise your definition of infection.

    There are perhaps better definitions here:

    There is a number of definitions on that page, the first one being:

    There is a very good definition further down the page, with illustrative Figures.
    SOC likes this.
  7. Leopardtail

    Leopardtail Senior Member

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    This one is fairy simple to answer. The immune system is highly demanding of energy hence if Mitochondria are now working well (or any other aspect of energy generation) then one would expect problems to occur. Other energy deficit illnesses (e.g. diabetes) also feature immune dysfunction.

    Once you start poking around in cells, and at enzymes, the extent to which everything is interconnected and cyclic becomes much higher than in inter-organ function. Various hormones however are also involved in regulating the immune system including both Melatonin and Vitamin D.

    The statement that 'it cannot be exclusively metabolic' could be taken as either true because so many systems are affected, or a bit brave since the only way to disprove it is to supplement energy (ATP) which is not possible. I would point out thought that one cannot claim with certainty the ME is exclusively any particular system or dysfunction, were that the case then we would have a clear etiology and a probable cure.

    The level of exhaustion (fatigue is as silly word to use in my view) in ME is so great that it surpasses pretty much every other disease, hence I would be inclined to agree with the simple common sense view expounded that it must be metabolic irrespective of the cause. Compare it with Type I diabetes in which the cause is auto-immune but the havoc and the treatment are both metabolic.
    Last edited: Jun 29, 2014
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  8. Leopardtail

    Leopardtail Senior Member

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    Several genes were identified in type I diabetes a couple of decades ago Alex, hence the higher familial incidence.
  9. Leopardtail

    Leopardtail Senior Member

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    It's not offered routinely anywhere because psychotic psychiatrists have dominated the debate (poor deliberate pun).
    It needs saying though that the Myhill papers strongly show mito dysfunction, but have not definitively shown what causes the dysfunction, what makes us more vulnerable etc. That needs wider scale research by more people. Newton et al have also shown greater lactic acid production in muscle. The biggest issue is that funding has gone from being primarily psychiatric to primarily immune for research. One dogma has been replaced by another despite mito based research showing better results. You should also check Titelbaum's research on Ribose (replicated at the university of Leeds but not published).
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  10. Leopardtail

    Leopardtail Senior Member

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    Agreed, but equally if you have immune dysfunction, one can't rule out more being present simply because the immune system cant cope with them. Some people are made very ill by Lyme/Mono others aren't hence whether those dieaseases are genuinely infectious or simply triggers is equally debatable especially given their close symptomatic correlation with ME.
  11. Leopardtail

    Leopardtail Senior Member

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    Because no single Enterovirus is universally present. But mainly because a handful of psychiatric crackpots dominant the medical press and governmental regulation.
  12. Leopardtail

    Leopardtail Senior Member

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    Doctors only consider an infection 'detected' if over a certain number of a single infection are present. Also they more usually detect infection by looking for a single type of Antibody - meaning if you immune system is not working well their tests fail.
  13. Gingergrrl

    Gingergrrl Senior Member

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    Thank you for all the detailed responses to my question to @Elph68 and I wish I had a more scientific background so I could grasp it all. It sounds like you are saying the tests fail b/c most doctors either say "The antibodies are from a prior infection and found in 90% of the population blah, blah, blah" or someone's immune system is too compromised to even create the antibodies. Is that correct?

    As for the ATP/Mito profile, is that something that Dr. Myhill is standardly testing in Britain but the U.S. is just not offering it? My ND ordered some kind of Mito test kit for me that is taking forever to arrive. I see her this Tues and am hoping it is now here so I can do the test and let you guys know what it is called.
  14. Leopardtail

    Leopardtail Senior Member

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    it may be the same test, myhill offers it internationally.
  15. Elph68

    Elph68 Senior Member

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    We will just have to agree to disagree MeSci.

    The medical profession has it wrong!

    An undetectable infection is one that does not fit within the current medical definitions nor current pathology tests...

    Pathogenic normal flora that cause chronic and debilitating disease .... is the undetectable infection!
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  16. Elph68

    Elph68 Senior Member

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    thank you leopard tail ..... Mixed species, acting in the same way causing disease is the same result of one species becoming dominant and causing disease .... that is why it is undetectable .....
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  17. Gingergrrl

    Gingergrrl Senior Member

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    @Leopardtail I think my ND was not familiar with Sarah Myhill when I mentioned her and that this is a different test but I really am not sure.
  18. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    I don't dispute the likelihood that some infections are impossible to detect using standard tests. This has been widely discussed on Phoenix Rising.

    What I was questioning was your definition of an infection as being "an overgrowth of known pathogens" (my bolding). It is very frequent that the pathogen is unknown. And of course tests do not always identify them. But they are still infections.
    SOC likes this.
  19. Leopardtail

    Leopardtail Senior Member

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    perhaps overgrowth of known microbes (e.g. candida) might be a better description? Where medics don't consider them harmful, but this ceases to be true with overgrowth, thus crossing the gap between benign and pathogenic?
  20. Elph68

    Elph68 Senior Member

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    Well MeSci, regardless of whether my interpretation of infection is correct or in line with the medical process robots, different species of 'normal flora' bacteria, acting in the same way, causing chronic disease is an undetectable infection in today's medical system ....

    And by the way, my experience to date with the medical profession that you hold in so high regard ... Has not been great!! I am being sued by an infectious disease specialist, a urologist, 2 gp's and the pathologists for defamation ... I have publicly accused them of misdiagnosis, and for racketeering ....

    I told them to bring it on!!! It is going to be very public!!!

    This disease is caused by (in some/most cases) different strains of normal flora acting in the same way (crossing the mucosal barrier) and interacting directly with the immune system, causing chronic disease .... The undetectable infection ......

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