Hello everybody, As a physician and a patient of CFS for the last 3 years, I have an opportunity to view this from both sides. I made some interesting observations with my illness, and my training has helped me to look at it deeply. My theory is that CFS is a metabolic condition- not infectious, immunologic, neurologic, muscular, gastrointestinal etc. There is a fundamental abnormality in energy production and distribution- and this is the defect present in ALL patients. Other symptoms, present in some and not others, are secondary to this. Here is an explanation of this theory, in a copy of the email I sent to Dr. Ron Davis, who heads the CFS research center at Stanford. Hello Dr. Davis, Thank you for starting the CFS research center at Stanford. As a 44-yr old family physician who has been suffering with this for 3 years, the last two of them homebound, I am aware of both sides of the coin. I was excited to see that your center will be working on microarray analysis to look for gene expressions in the mitochondrial genomes as well. I had been wondering if such research was being done at all, and I'm thrilled to see that you will be. Two common themes here, lack of energy and maternal transmission, both point towards mitochondria, and I'm positive you will find the culprits here! My theory is that CFS is a disease of metabolism- since during periods of good energy, all my other symptoms like brain fog, headache, muscle pains, tremors, constipation, chemical sensitivities, photo and phono phobia, depression, anxiety, all disappear. I feel completely normal! But when my energy levels are low, they all come back like drinking buddies (of fatigue). There are clearly anomalies of energy production ( low energy is the common denominator in ALL patients, regardless of their other symptoms); and also energy distribution (like the occasional boosts in energy; and the delayed build up of energy after an activity). My suggestion is if you could please look into mitochondrial gene expressions by microarrays during such episodes of low and 'normal' energy states, you will hit the motherload! This is clearly a syndrome, and all other systems affected are secondary to this metabolic abnormality, and in my opinion, looking at other systems infectious, immunologic, neurologic, gastrointestinal, etc, will not be of substantial benefit. Please know that I will be available to help in any way I can in the research of my disabling condition! Thank you!