Diagnosing Chronic Fatigue Syndrome
http://medicalphysicsweb.org/cws/article/research/48594
RESEARCH
Feb 10, 2012
Diagnosing chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a debilitating condition that currently occurs in up to 0.4% of Europe's population. Despite the sizeable volume of research into CFS, no bedside diagnostic tool currently exists, leaving patients frustrated and seeking answers. Now, however, a pilot study carried out in the UK and published in Physiological Measurement, has shown that a simple optical technique has the potential to identify individuals with CFS (Physiol. Meas. 33 231).
"Our research study explored how we might use the properties of the peripheral pulse as a diagnostic tool for CFS," said Julia Newton, an honorary consultant physician at the Newcastle upon Tyne Hospitals NHS Foundation Trust and within Newcastle University's Institute for Ageing and Health. "Pulse wave abnormalities were observed in CFS and represent a potential objective measure to help differentiate between CFS patients and healthy controls."
A difficult diagnosis
CFS can affect all ages and its cause is unclear. One of the current difficulties in recognising CFS is the lack of a suitable diagnostic biomarker. Aware that abnormalities of the autonomic nervous system are observed in over three quarters of those with CFS and that orthostatic intolerance is a common symptom, Newton and her collaborators initiated a pilot study to investigate whether peripheral pulse characteristics on orthostasis could provide the biomarker that clinicians and patients alike are searching for.
"The normal homeostatic response to standing is to preserve the brain at all costs," explained Newton. "The body therefore aims to do what it can to get the blood back to the brain against gravity by increasing the heart rate and constricting the peripheral blood vessels. Our study focused on measuring and assessing pulses from multiple peripheral sites simultaneously in both CFS patients and controls in response to a posture change."
Multiple peripheral pulse measurements
The technique employed by the team is known as PPG, or photoplethysmography. PPG is a simple and safe optical way of measuring the pulse at easy-to-access peripheral sites such as the ear lobe, finger tips or toe pads.
The researchers recruited 28 subjects: 14 patients with confirmed CFS and 14 healthy control volunteers. For each person in turn, the team simultaneously acquired data from the right and left ear lobes, the index fingers and big toes using its award-winning multi-site PPG technology. Baseline measurements were made with the patient lying supine on a tilt table and collected over 10 minutes. The patient was then tilted upright to an angle of 70 degrees to the horizontal and the changes in pulse assessed over a three minute period whilst they remained in this near-upright position. An electrocardiogram was also collected during the measurements.
"With each heartbeat, the blood volume changes in the vascular bed of the tissue and the amount of light shone onto the skin by the probes varies in synchrony with this, giving a clear pulse with each heart beat," explained John Allen, a clinical scientist from the Regional Medical Physics Department of Newcastle's Freeman Hospital. "The pulse waveform has many features in terms of its size, shape and the time for it to get from the heart to the periphery as well as beat-by-beat variability. We used special computer analysis techniques to extract various pulse features and compared these to data from normal subjects to provide the diagnostic information."
Following off-line analysis, the team found that there were significant differences between the CFS group and the controls for combinations of pulse amplitude and timing measurements, with a strong diagnostic bias coming from the ear lobe site.
"We think that the ear measurements could be influenced by cerebral autoregulation (CA), the reflexes that preserve brain blood flow at all costs," said Newton. "Cognitive problems are common in those with CFS. Further research applied to a larger number of subjects should help decide the most reliable combination of pulse features to measure so that the technique can be applied to a general population for screening of CFS with full confidence."
About the author
Jacqueline Hewett is a freelance science and technology journalist based in Bristol, UK.