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CFS = Immune Dysfunction?

Discussion in 'Immunological' started by lnester7, Jan 6, 2013.

  1. Hip

    Hip Senior Member

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    I have just had a quick Google, and this study found that the Th17 cytokines IL-17 and IL-23 were unchanged (normal) in (female) ME/CFS patients, so there may not be much consistency in these results from one study to the next.

    My understanding is that the Th17 immune response is a rather specialized one, that only comes into play to fight off a small subset of pathogens, which include Staphylococcus aureus and Candida albicans. So perhaps only ME/CFS patients that have co-infections with these specific pathogens will have raised Th17?

    Raised Th17 does compromise both intestinal and blood-brain barrier integrity, so lowering Th17 with N-acetylglucosamine may help repair these barriers.
  2. LaurieL

    LaurieL Senior Member

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    This is interesting.....in some of my learning from the Autism treatments, they talk about poorly sulfated GAG's in which robs the ability of these to resist infection. Those with chronic infections have an accelerated turnover rate of the GAG's. They mention the natural form of vitamin A (the cis form) is important for the formation of T and B cells for long term immune memory to develop and it is also needed for NK cells. Cis vitamin A can bypass blocked G-protein pathways and turn on central retinoid receptors. Which ROR gamma is apart of.

    The gut sheds sulfated GAG's (glucosaminoglycans) during inflammation and leads to leaky gut and excess opiod problems....

    So perhaps cis form Vitamin A might be beneficial?
  3. SOC

    SOC Moderator and Senior Member

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    :confused: No I'm really mind-boggled. My test results are so different from the ones in the referenced study it's almost laughable. Most of the cytokines that were abnormal in the ME/CFS patients in the study are normal in me and most that were normal in ME/CFS patients are abnormal in me.

    If those cytokine abnormalities were used as biomarkers, I wouldn't be diagnosed with ME/CFS. There's an interesting thought.
  4. SOC

    SOC Moderator and Senior Member

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    Can't hurt and certainly worth a try. :) Thanks!
  5. LaurieL

    LaurieL Senior Member

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    [​IMG]

    http://www.nature.com/nri/journal/v8/n9/fig_tab/nri2378_F3.html

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003750/

    So perhaps the cis form of Vitamin A might or might not beneficial, depending on where one sits with Th17?
  6. Hip

    Hip Senior Member

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    I find vitamin A quite beneficial for my ADHD-like symptoms, and it also reduces my sinus inflammation. I take 25,000 IU of natural vitamin A daily for this purpose (it's Now® vitamin A derived from fish liver oil).
  7. LaurieL

    LaurieL Senior Member

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    I found it beneficial as well, I take mine in Cod Liver Oil cap's from Kirkman Lab's. I also take EPO to address those intestinal GAG's. :)
  8. SOC

    SOC Moderator and Senior Member

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    So any idea where to find cis form vitamin A? My basic search didn't find any obvious products. Does one just take cod liver oil?
  9. LaurieL

    LaurieL Senior Member

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    The cis form is found in Cod liver oil. Through my research into the Autism forums, they recommended Kirkman labs as being unadulterated, and no contaminents consistently found in their product. I guess quite a few products out there, Cod Liver oil, are adulterated with the synthetic form of vitamin A, and those are the forms that shut down the GAG's and retinoic receptors. So I stopped my vitamin A supplement and went to this one. It is amazingly cheaper than what I was paying for the vitamin A. It has 250 capsules for about 20 bucks. Considering other Cod Liver supps, I didn't think that was too bad.
  10. lnester7

    lnester7 Seven

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