For getting tested for Chronic Inflammatory Response Syndrome (CIRS), Dr. Shoemaker recommends: neuropeptide regulation of inflammation (MSH, VIP) inflammatory processes out of control (TGF beta-1, C4a, MMP-9) gene susceptibility (HLA DR) hormonal dysregulation (ADH/osmolality, ACTH/cortisol, androgens) hypoxia inducible factor regulated compounds (VEGF, erythropoietin, TGF beta-1) autoimmunity (TGF beta-1, AGA, ACLA, ANA, ANCA, actin) cellular basis of immune regulation (TH17 immunity, TGF beta-1) I know there isn’t any one of these tests that will definitely confirm anything; rather it’s having multiple tests and having them all point towards a positive diagnosis for CIRS. Does anyone have a recommendation for the order of getting these tests done? Or have people opted to get most (or all) of these labs at once after they suspect being sick with CIRS? We are hoping with after HLA, MSH, Leptin, C4a, TGF-b1 we will have enough data to work with her doctor on a positive (hopefully) diagnosis (so we can start treatment!!). Tests my wife has had: HLA (DRB1: 01, DRB1: 14; DRB3: 52B; DQ: 05) MSH (11) Leptin (6.4) Test we were planning on getting next (based on Dr. Shoemaker’s writings that C4a: C4a TGF-b1 The rest (VIP, MMP-9, VEGF, and a bunch of other long acronym ones) we were planning on waiting on given that they’re (I believe) more difficult to get tested because they require dry ice shipment and probably other factors as well.