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Hunting down the cause of ME/CFS & other challenging disorders - Lipkin in London
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CFS / CIRS recommended diagnostic plan?

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by concerned_husband, Nov 11, 2013.

  1. concerned_husband

    concerned_husband

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    Seattle WA
    For getting tested for Chronic Inflammatory Response Syndrome (CIRS), Dr. Shoemaker recommends:
    1. neuropeptide regulation of inflammation (MSH, VIP)
    2. inflammatory processes out of control (TGF beta-1, C4a, MMP-9)
    3. gene susceptibility (HLA DR)
    4. hormonal dysregulation (ADH/osmolality, ACTH/cortisol, androgens)
    5. hypoxia inducible factor regulated compounds (VEGF, erythropoietin, TGF beta-1)
    6. autoimmunity (TGF beta-1, AGA, ACLA, ANA, ANCA, actin)
    7. cellular basis of immune regulation (TH17 immunity, TGF beta-1)

    I know there isn’t any one of these tests that will definitely confirm anything; rather it’s having multiple tests and having them all point towards a positive diagnosis for CIRS.

    Does anyone have a recommendation for the order of getting these tests done? Or have people opted to get most (or all) of these labs at once after they suspect being sick with CIRS? We are hoping with after HLA, MSH, Leptin, C4a, TGF-b1 we will have enough data to work with her doctor on a positive (hopefully) diagnosis (so we can start treatment!!).

    Tests my wife has had:
    1. HLA (DRB1: 01, DRB1: 14; DRB3: 52B; DQ: 05)
    2. MSH (11)
    3. Leptin (6.4)

    Test we were planning on getting next (based on Dr. Shoemaker’s writings that C4a:
    1. C4a
    2. TGF-b1
    3. The rest (VIP, MMP-9, VEGF, and a bunch of other long acronym ones) we were planning on waiting on given that they’re (I believe) more difficult to get tested because they require dry ice shipment and probably other factors as well.
     
  2. lnester7

    lnester7 Seven

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    USA
    wait is this a new name??? or different disease Chronic Inflammatory Response Syndrome (CIRS)??
     
  3. concerned_husband

    concerned_husband

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    Seattle WA
    Apologies, by CFS I meant Chronic Fatigue Syndrome and CIRS is Chronic Inflammatory Response Syndrome.
     
  4. SickOfSickness

    SickOfSickness Senior Member

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    I have never heard of CIRS. I googled and CIRS appears to be for symptoms after mold exposure.
     
  5. concerned_husband

    concerned_husband

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    Yes, that's correct. CIRS is essentially a large umbrella that other inflammatory illnesses can be categorized under (Fibyro, Chronic fatigue, Lyme's, and others).

    This grouping was done by Shoemaker based on the commonality of symptoms and that some test results that are similar (while some are obviously going to be different as the actual different illnesses can manifest in each test differently depending on the condition).
     

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