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CFS and CD19 gene - article

Discussion in 'Latest ME/CFS Research' started by Daffodil, Feb 3, 2013.

  1. Daffodil

    Daffodil Senior Member

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    The CD19 or Cluster of Differentiation 19, is a human protein that is encoded by the CD19 gene. In other words it is a protein that is told how to act and what to do by the CD19 gene. This specific protein is related to the immune system and more specifically the B cell and follicular dentritic cells. This gene decreases the threshold for stimulation of the cell to react to an antigen, or protein that is foreign to the body.
    Researchers have found that the CD19 blood test will help to estimate the extent of the chronic fatigue syndrome in the body. And in a study published by Dr. Uckun researchers found that the CD 19 gene plus the IgM cells were deficient in 94% of patients in their study with CFS. It was postulated that it was this immune-deficiency was in part responsible for symptoms of chronic fatigue.
    This also has implications for treatment of the condition. As a result the team used a drug, Leucovorin, a folinic acid derivative, for several months. They found that 81% of the patients reported improvement within two months. Unfortunately, at the conclusion of the study the researchers didn’t perform a cytometry measurement that would have given insight into the clinical efficacy of the drug leaving them only with the functional reports of improvement.


    Read More of This Article Here: http://www.natural-holistic-health.com/cd19-blood-test-and-chronic-fatigue-syndrome/?utm_source=rss&utm_medium=rss&utm_campaign=cd19-blood-test-and-chronic-fatigue-syndrome
    Moxie, sianrecovery and taniaaust1 like this.
  2. Dolphin

    Dolphin Senior Member

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    Looks like it's this 2006 study:

    http://www.ncbi.nlm.nih.gov/pubmed/16889122

  3. Daffodil

    Daffodil Senior Member

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    looks some someone on the other board tried Leucovorin with good results....
  4. overtrain

    overtrain Medical Mafia needs to die via this virus.

    FYI: earlier background from 1994, apparently, re follicular dendritic cells, B cell downreg, antigen, etc. Nothing on folinic, but thought might be interesting reference anyway.


    Exp Med. 1994 April 1; 179(4): 1173–1184.

    PMCID: PMC2191436
    Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines:
    Full Text ---- The Full Text of this article is available as a PDF HERE: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191436/


  5. Daffodil

    Daffodil Senior Member

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    interesting. i wonder if they have ruled out EBV latent proteins as a potential cause of CFS yet. i would be surprised if they hadnt....
  6. taniaaust1

    taniaaust1 Senior Member

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    Sth Australia
    Very interesting. A specialist put me on folinic acid due to having MTHFR polymorphism.. and the new supplements for this are certainly helping. Now Im going to wondering if it is helping due to the MTHFR or due to the CFS.
  7. roxie60

    roxie60 Senior Member

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    Is / are there specific rs# SNPs for CD19 that they are looking at being related to CFS? I also found (today) an old article from 1999 that said they found a promising blood test to use to identify CFS http://www.prohealth.com/library/showarticle.cfm?libid=615 and I wonder where this went if anywhere. I read the CD19 article and other than the links to Fatigue Fighter product I dont see where there is enough info to determine how one gets tested for CD19 (I know it is a blood test). I'm going to look at my CD19 on 23and Me. Anyone making a possible link to this CD19 as valid ? For some of us our symptoms wax and wane (from bed ridden at times to more functional at others although never without some symptom/s to deal with daily) does this blood test result mean? I am about to be tested for CBC, homosystiene , CMP again and ammonia. Anyone have had ammonia serum test? Not sure why she wants homosyteien, it was low last time. I'm rambling, my brain function has not been to good last 24 hrs, well really everyday just not all day. I am so tired of all of it, symptoms, Drs, tests, judgemental people.....I was very angry yesterday, almost raging, might be due to the Nuvigil I have taken the last four days (75mg) or maybe my long lost hormones spiked for a day. Will see, just took another nuvigil 75mg, been taking to try and give me mental and pyhysical energy for part of the day. I had gone a few weeks and could acomplish very little. My thought process focus has been jumping all around.
  8. roxie60

    roxie60 Senior Member

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    Central Illinois, USA
    I found 3 SNPs for CD19 and my results, anyone have any insight on these?:
    Rs35979293 TT

    Rs2904881 CC

    Rs2070962 TT
  9. Valentijn

    Valentijn Activity Level: 3

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    Literally everyone seems to have Rs2904881, so that one can be safely ignored.

    The other two are a bit interesting, but not uncommon in Europeans (around 15%). There's no mutation associated with them, so they're unlikely to have a big impact on the gene function. But there's not been any research showing they have an impact on anything, and just one study showing that one of them doesn't have an impact on systemic sclerosis.
  10. Guido den Broeder

    Guido den Broeder *****

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    Rotterdam, The Netherlands
  11. lansbergen

    lansbergen Senior Member

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