• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

CFS and CD19 gene - article

Daffodil

Daffodil

Senior Member
Messages
5,875
The CD19 or Cluster of Differentiation 19, is a human protein that is encoded by the CD19 gene. In other words it is a protein that is told how to act and what to do by the CD19 gene. This specific protein is related to the immune system and more specifically the B cell and follicular dentritic cells. This gene decreases the threshold for stimulation of the cell to react to an antigen, or protein that is foreign to the body.
​
Researchers have found that the CD19 blood test will help to estimate the extent of the chronic fatigue syndrome in the body. And in a study published by Dr. Uckun researchers found that the CD 19 gene plus the IgM cells were deficient in 94% of patients in their study with CFS. It was postulated that it was this immune-deficiency was in part responsible for symptoms of chronic fatigue.
This also has implications for treatment of the condition. As a result the team used a drug, Leucovorin, a folinic acid derivative, for several months. They found that 81% of the patients reported improvement within two months. Unfortunately, at the conclusion of the study the researchers didn’t perform a cytometry measurement that would have given insight into the clinical efficacy of the drug leaving them only with the functional reports of improvement.


Read More of This Article Here: http://www.natural-holistic-health.com/cd19-blood-test-and-chronic-fatigue-syndrome/?utm_source=rss&utm_medium=rss&utm_campaign=cd19-blood-test-and-chronic-fatigue-syndrome
 
D

Dolphin

Senior Member
Messages
17,567
Daffodil said:
The CD19 or Cluster of Differentiation 19, is a human protein that is encoded by the CD19 gene. In other words it is a protein that is told how to act and what to do by the CD19 gene. This specific protein is related to the immune system and more specifically the B cell and follicular dentritic cells. This gene decreases the threshold for stimulation of the cell to react to an antigen, or protein that is foreign to the body.

Researchers have found that the CD19 blood test will help to estimate the extent of the chronic fatigue syndrome in the body. And in a study published by Dr. Uckun researchers found that the CD 19 gene plus the IgM cells were deficient in 94% of patients in their study with CFS. It was postulated that it was this immune-deficiency was in part responsible for symptoms of chronic fatigue.
This also has implications for treatment of the condition. As a result the team used a drug, Leucovorin, a folinic acid derivative, for several months. They found that 81% of the patients reported improvement within two months. Unfortunately, at the conclusion of the study the researchers didn’t perform a cytometry measurement that would have given insight into the clinical efficacy of the drug leaving them only with the functional reports of improvement.


Read More of This Article Here: http://www.natural-holistic-health.com/cd19-blood-test-and-chronic-fatigue-syndrome/?utm_source=rss&utm_medium=rss&utm_campaign=cd19-blood-test-and-chronic-fatigue-syndrome
Click to expand...
Looks like it's this 2006 study:

http://www.ncbi.nlm.nih.gov/pubmed/16889122

Arzneimittelforschung. 2006;56(6):399-404.

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Lundell K, Qazi S, Eddy L, Uckun FM.

Source
Parker Hughes Institute and Parker Hughes Clinics, St. Paul, MN 55113, USA.

Abstract

A high incidence of severe B-cell immunodeficiency and chronic reactivated Epstein-Barr virus (EBV) infection in patients with chronic fatigue syndrome (CFS) is reported herein.

Of the 58 patients evaluated, 100% had evidence of prior EBV exposure and 72% had evidence for reactivated EBV infection.

Notably, 94% of CFS patients had B-cell immunodeficiency with a marked depletion of their CD19+IgM+ mature B-lymphocyte population.

A remarkable 81% of CFS patients experienced subjective improvement of their symptoms after treatment with folinic acid (CAS 58-05-9, leucovorin).

The findings provide unprecedented evidence that CFS frequently is a folinic acid responsive clinical entity accompanied by B-cell immunodeficiency and inappropriate antibody responses to EBV.

PMID: 16889122 [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances
Click to expand...
 
overtrain

overtrain

Medical Mafia needs to die via this virus.
Messages
147
Location
Difference between a steer & an M.D.?
FYI: earlier background from 1994, apparently, re follicular dendritic cells, B cell downreg, antigen, etc. Nothing on folinic, but thought might be interesting reference anyway.


Exp Med. 1994 April 1; 179(4): 1173–1184.

PMCID: PMC2191436
Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines:
Full Text ---- The Full Text of this article is available as a PDF HERE: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191436/


 
Daffodil

Daffodil

Senior Member
Messages
5,875
interesting. i wonder if they have ruled out EBV latent proteins as a potential cause of CFS yet. i would be surprised if they hadnt....
 
T

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
A remarkable 81% of CFS patients experienced subjective improvement of their symptoms after treatment with folinic acid (CAS 58-05-9, leucovorin).
Click to expand...

Very interesting. A specialist put me on folinic acid due to having MTHFR polymorphism.. and the new supplements for this are certainly helping. Now Im going to wondering if it is helping due to the MTHFR or due to the CFS.
 
roxie60

roxie60

Senior Member
Messages
1,791
Location
Central Illinois, USA
Is / are there specific rs# SNPs for CD19 that they are looking at being related to CFS? I also found (today) an old article from 1999 that said they found a promising blood test to use to identify CFS http://www.prohealth.com/library/showarticle.cfm?libid=615 and I wonder where this went if anywhere. I read the CD19 article and other than the links to Fatigue Fighter product I dont see where there is enough info to determine how one gets tested for CD19 (I know it is a blood test). I'm going to look at my CD19 on 23and Me. Anyone making a possible link to this CD19 as valid ? For some of us our symptoms wax and wane (from bed ridden at times to more functional at others although never without some symptom/s to deal with daily) does this blood test result mean? I am about to be tested for CBC, homosystiene , CMP again and ammonia. Anyone have had ammonia serum test? Not sure why she wants homosyteien, it was low last time. I'm rambling, my brain function has not been to good last 24 hrs, well really everyday just not all day. I am so tired of all of it, symptoms, Drs, tests, judgemental people.....I was very angry yesterday, almost raging, might be due to the Nuvigil I have taken the last four days (75mg) or maybe my long lost hormones spiked for a day. Will see, just took another nuvigil 75mg, been taking to try and give me mental and pyhysical energy for part of the day. I had gone a few weeks and could acomplish very little. My thought process focus has been jumping all around.
 
V

Valentijn

Senior Member
Messages
15,786
roxie60 said:
I found 3 SNPs for CD19 and my results, anyone have any insight on these?:
Rs35979293TT
Rs2904881 CC
Rs2070962 TT
Click to expand...
Literally everyone seems to have Rs2904881, so that one can be safely ignored.

The other two are a bit interesting, but not uncommon in Europeans (around 15%). There's no mutation associated with them, so they're unlikely to have a big impact on the gene function. But there's not been any research showing they have an impact on anything, and just one study showing that one of them doesn't have an impact on systemic sclerosis.
 
You must log in or register to reply here.