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Center for Hypotension at New York Medical College looking for POTS and VVS patients

Discussion in 'Active Clinical Studies' started by ahimsa, Sep 17, 2015.

  1. ahimsa

    ahimsa Rarely on PR now

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    I saw this at http://www.dysautonomiainternational.org/page.php?ID=225

    I don't know whether patients with a diagnosis of either ME or CFS in addition to POTS or VVS can be part of the study but I thought I'd post it here just in case.

    Enrolling Now - Droxidopa in POTS and VVS
    Study Title: Northera (Droxidopa) Improves POTS and Postural Vasovagal Syncope


    The Center for Hypotension at New York Medical College, lead by Dr. Julian Stewart, is seeking individuals aged 18-30 diagnosed with POTS (postural orthostatic tachycardia syndrome) or VVS (vasovagal syncope, also known as NCS or neurocardiogenic syncope) to participate in a research study, to help determine if droxidopa (brand name Northera) is an effective treatment for POTS or VVS. While vasovagal syncope includes both postural syncope due to orthostatic intolerance upon standing and emotionally driven syncope (fear of needles, fainting at the sign of blood, etc.), this study will only focus on posturally-driven VVS.

    The researchers are recruiting VVS patients with at least 2 episodes of vasovagal fainting in the past 12 months, and patients with POTS who have had symptoms for 6 months or more. They can accept patients who have both POTS and VVS.

    It is thought that many of the symptoms of POTS and VVS are caused by abnormalities in the way in which blood volume (the amount of blood in your circulatory system) shifts when you go from lying down to standing upright. Blood pressure is maintained by the contraction of blood vessels. We want to determine whether droxidopa will improve blood vessel contraction in VVS and POTS and whether this improves quality-of-life for patients.

    The study will consist of two office visits, at least a week apart.

    On the first day, you will remain lying down on a table for 2-3 hours while being hooked-up to various non-invasive monitoring devices. The monitoring devices include a heart rate monitor, beat to beat blood pressure, a transcranial doppler [a sonorgram of the blood flow in your brain], and a near-infrared spectrospcopy [a red light placed on your forehead that can measure oxygen levels in your brain]. You will be monitored for about 30 minutes prior to the administration of either Northera 600mg or placebo (a capsule containing no medication) by mouth. After 2 hours of monitoring while lying down, a 70 degree upright tilt test will be performed for approximately 10 minutes. You will be then be scheduled to come back a week or so later to repeat the testing and receive the treatment you did not receive on the first visit, either Northera or placebo.

    Patients will have a total of 2 days of testing and will be reimbursed $150 per day.

    If interested or if you would like more information, please contact:

    Courtney Terilli, Research Coordinator
    The Center for Hypotension
    Department of Pediatrics
    19 Bradhurst Avenue, Suite 1600 South
    Hawthorne, New York 10532

    Email: courtney_terilli@nymc.edu
    Phone: 914-593-8888
     
    merylg likes this.

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