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CD4/CD8 Testing.

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by Ema, Nov 26, 2013.

  1. Ema

    Ema Senior Member

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  2. SOC

    SOC Moderator and Senior Member

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    Are you aware that the NK cell dysfunction most common in ME is not NK cell numbers, but NK cell function? The test you're looking at doesn't test for function. I wouldn't expect most of the results from that test to come back abnormal, so it might not be worth the cost.

    That said, my daughter does have low NK cell number and I have low CD8+ cell number, both of which would show up on the test you're considering. They're just not the most common immune dysfunction in ME/CFS.
  3. Ema

    Ema Senior Member

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    Thanks @SOC!

    I didn't think that Labcorp tested for NK cell function which is why I didn't ask about that in particular.

    But maybe I am wrong?
  4. WillowJ

    WillowJ Senior Member

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    Last edited: Nov 26, 2013
    SOC likes this.
  5. acer2000

    acer2000 Senior Member

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    Labcorp has a variety of panels that measure T and B cells, phenotypes, NK cells listed via that link you posted. These are ordered sometimes and can have interesting info about your immune system. But the previous posters are correct, they aren't listing the NK cell function assay – just tests that show you the count. Both count and function could be informative, but it really just depends on why your doctor wants to order the test to begin with.

    Another thing you should know about the NK cell function assay is that its very time sensitive. It needs to get to the lab right away to be accurate. Its also typically run against a control. I don't know if these large commercial labs do that or not.

    That being said, Labcorp will send the NK cell function assay out to a reference lab (recently Viracor but in the past Focus) if you doctor sets it up with them. However, there is no advantage to you doing it through them. And the end of last year they started billing with the wrong procedure codes for the test and it now causes practically everyone who gets the test through them to have it rejected by their insurance. I'd see if your doctor can order it through Focus or Viracor directly, or use Quest (who uses Focus) and seems to bill things correctly. Also Dr. Klimas lab in Miami will do the tests. If you do it through labcorp there is a high chance you will be stuck with a $700 bill.
    SOC and Ema like this.
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    if u do get the cd4/8 ratio, try to get the individual cd4 and cd8 numbers too. Out of the 7 billion cd tests i have had the ratio has only been abnormal once but the individual cd4/cd8 numbers have always been elevated.
  7. SOC

    SOC Moderator and Senior Member

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    I don't know if Labcorp does one. I get mine at Miami U's (now NOVA's) immune lab. My local lab told me that Mayo does NK function, too.
  8. Ema

    Ema Senior Member

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    I'm trying to make a case that I have an adenosine deaminase deficiency based on genetic mutations. These genetic mutations in their most severe form cause SCID, a disease until recently that was generally fatal before age 3. It is said that carriers are not symptomatic but I am not sure how they know that!

    So I am trying to "prove" that I have fewer than "normal" levels of T, B, and NK cells...it shouldn't be too hard to fall somewhere in that overly broad range, right?

    Cell typeNormal lymphocyte countX-SCID count
    T-cells 5,500 200
    B-cells800 1,300
    NK cells800 <100
    TotalSix months: 7,300 <2,000
    Last edited: Nov 26, 2013
  9. SOC

    SOC Moderator and Senior Member

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    What is this immune cell data? Is it something for SCID diagnosis?
  10. Ema

    Ema Senior Member

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    Yes, for X-SCID. I figure my levels should be less than normal but higher than SCID.
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  11. SOC

    SOC Moderator and Senior Member

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    I see. :) That must be a different measure than my data since the normal ranges are quite different. Am I reading it correctly that B-cell count in X-SCID is higher than the normal count?
  12. Ema

    Ema Senior Member

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    This is all very complicated and I'm still learning. But in that type of x-linked SCID, B cells are normal to high. I'm not sure about other forms but it probably says in this light reading.

    http://www.springer.com/cda/content...0785378-c1.pdf?SGWID=0-0-45-655414-p173815604

    I am trying to determine a profile for myself and then compare to these immunodeficiencies.

    Cheney wrote about these deficiencies as early as 2005. I'm trying to find out from him if he ever treated anyone with the synthetic enzyme replacement successfully.
    SOC likes this.
  13. SOC

    SOC Moderator and Senior Member

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    Great find! I'm definitely going to read through that since daughter and I have several immune deficiencies. Good luck!
    Ema likes this.

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